Expression, regulation and mechanism of action of the miR-17-92 cluster in tumor cells (Review).
Expression, regulation and mechanism of action of the miR-17-92 cluster in tumor cells (Review).
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DOI：
10.3892/ijmm.2017.3164
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发表时间：
2017-12
影响因子：
5.4
通讯作者：
Luo H
中科院分区：
文献类型：
--
作者：
Fang LL;Wang XH;Sun BF;Zhang XD;Zhu XH;Yu ZJ;Luo H
MicroRNAs(MiRNAs)是一类短小的单链非编码RNAs，通过在转录后水平上降解mRNA来调控真核生物中的基因表达。MiRNAs的调控涉及多种生物学过程，如细胞分化、增殖、转移、代谢、细胞凋亡、肿瘤发生等。MiRNAs也是疾病诊断和预后的有力工具。MiR-17-92簇是研究最广泛的microRNA簇之一，由6个成熟的miRNA成员组成，包括miR-17、miR-18a、miR-19a、miR-19b、miR-20a和miR-92a。MiR-17-92簇最初被认为与肿瘤的发生有关，但目前的研究表明，miR-17-92簇在多种肿瘤细胞和癌症类型中表达上调；因此，该簇已被确定为一个潜在的癌基因。考虑到miR-17-92研究领域的日益增长的兴趣，本文综述了该簇在各种癌细胞中的表达和调控的最新进展，讨论了该簇在肿瘤发生和发展中的作用机制，并提出了miR-17-92簇成员的临床和治疗应用，如潜在的癌症生物标志物。
MicroRNAs (miRNAs), a class of short, single-stranded non-coding RNAs, regulate and control gene expression in eukaryotes by degrading mRNA at the post-transcriptional level. Regulation by miRNAs involves a plethora of biological processes, such as cell differentiation, proliferation, metastasis, metabolism, apoptosis, tumorigenesis and others. miRNAs also represent a powerful tool in disease diagnosis and prognosis. The miR-17-92 cluster, one of the most extensively investigated microRNA clusters, comprises six mature miRNA members, including miR-17, miR-18a, miR-19a, miR-19b, miR-20a and miR-92a. Originally identified as being involved in tumorigenesis, it is currently evident that the expression of the miR-17-92 cluster is upregulated in a wide range of tumor cells and cancer types; thus, this cluster has been identified as a potential oncogene. Considering the growing interest in the field of miR-17-92 research, we herein review recent advances in the expression and regulation of this cluster in various cancer cells, discuss the proposed mechanism of action for tumorigenesis and tumor development, and propose clinical and therapeutic applications for miR-17-92 cluster members, such as potential cancer biomarkers.
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