Role of osteoclasts in oral homeostasis and jawbone diseases.
Role of osteoclasts in oral homeostasis and jawbone diseases.
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DOI：
10.1002/osi2.1078
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发表时间：
2020-01
影响因子：
0.5
通讯作者：
Mishina Y
中科院分区：
文献类型：
--
作者：
Omi M;Mishina Y
颌骨是一种独特的结构，因为它具有多种咀嚼功能。鉴于颌骨的重塑速度比其他骨骼更快，颌骨中的骨细胞可能对局部和全身信号做出不同的反应，以调节骨重塑和适应。破骨细胞是负责去除旧骨的骨细胞，在骨重塑中发挥着重要作用。尽管破骨细胞的骨吸收是牙组织发育、稳态和修复所必需的，但过度的破骨细胞活性与牙周炎等口腔骨骼疾病有关。此外，用于防止肿瘤骨稳态的抗吸收药物可能会导致颌骨坏死，这是牙医最关心的问题。因此，了解破骨细胞在生理和病理条件下口腔稳态中的作用可以为骨骼疾病提供更好的针对性治疗方案，以维持患者的口腔健康。在这里，我们重点介绍颌骨与长骨相比的独特特征以及破骨细胞在颌骨特异性疾病中的参与。
The jawbone is a unique structure as it serves multiple functions in mastication. Given the fact that the jawbone is remodeled faster than other skeletal bones, bone cells in the jawbone may respond differently to local and systemic cues to regulate bone remodeling and adaptation. Osteoclasts are bone cells responsible for removing old bone, playing an essential role in bone remodeling. Although bone resorption by osteoclasts is required for dental tissue development, homeostasis and repair, excessive osteoclast activity is associated with oral skeletal diseases such as periodontitis. In addition, antiresorptive medications used to prevent bone homeostasis of tumors can cause osteonecrosis of the jaws that is a major concern to the dentist. Therefore, understanding of the role of osteoclasts in oral homeostasis under physiological and pathological conditions leads to better targeted therapeutic options for skeletal diseases to maintain patients’ oral health. Here, we highlight the unique features of the jawbone compared to the long bone and the involvement of osteoclasts in the jawbone-specific diseases.
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