Sophoridine alleviates hyperalgesia and anxiety-like behavior in an inflammatory pain mouse model induced by complete freund's adjuvant.
Sophoridine alleviates hyperalgesia and anxiety-like behavior in an inflammatory pain mouse model induced by complete freund's adjuvant.
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DOI：
10.1177/17448069231177634
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发表时间：
2023-01
期刊：
影响因子：
3.3
通讯作者：
中科院分区：
文献类型：
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作者：
Chronic pain, along with comorbid psychiatric disorders, is a common problem worldwide. A growing number of studies have focused on non-opioid-based medicines, and billions of funds have been put into digging new analgesic mechanisms. Peripheral inflammation is one of the critical causes of chronic pain, and drugs with anti-inflammatory effects usually alleviate pain hypersensitivity. Sophoridine (SRI), one of the most abundant alkaloids in Chinese herbs, has been proved to exert antitumor, antivirus and anti-inflammation effects. Here, we evaluated the analgesic effect of SRI in an inflammatory pain mouse model induced by complete Freund’s adjuvant (CFA) injection. SRI treatment significantly decreased pro-inflammatory factors release after LPS stimuli in microglia. Three days of SRI treatment relieved CFA-induced mechanical hypersensitivity and anxiety-like behavior, and recovered abnormal neuroplasticity in the anterior cingulate cortex of mice. Therefore, SRI may be a candidate compound for the treatment of chronic inflammatory pain and may serve as a structural basis for the development of new drugs.
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影响因子：
5.2
作者：
通讯作者：
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DOI：
10.1016/j.bbi.2020.11.030
发表时间：
2021-03
期刊：
Brain, behavior, and immunity
影响因子：
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作者：
Yi MH;Liu YU;Liu K;Chen T;Bosco DB;Zheng J;Xie M;Zhou L;Qu W;Wu LJ
通讯作者：
Wu LJ
影响因子：
4.6
作者：
Zhou Z;Qiu N;Ou Y;Wei Q;Tang W;Zheng M;Xing Y;Li JJ;Ling Y;Li J;Zhu Q
通讯作者：
Zhu Q
影响因子：
5.1
作者：
Rashid, Haroon Ur;Rasool, Shagufta;Martines, Marco Antonio Utrera
通讯作者：
Martines, Marco Antonio Utrera
影响因子：
4.7
作者：
通讯作者：
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