Maternal periconceptional alcohol consumption and gastroschisis in the National Birth Defects Prevention Study, 1997-2011.
Maternal periconceptional alcohol consumption and gastroschisis in the National Birth Defects Prevention Study, 1997-2011.
复制标题
DOI：
10.1111/ppe.12882
复制
发表时间：
2022-11
影响因子：
2.8
通讯作者：
Browne, Marilyn L.
中科院分区：
文献类型：
--
作者：
Fisher, Sarah C.;Howley, Meredith M.;Romitti, Paul A.;Desrosiers, Tania A.;Jabs, Ethylin Wang;Browne, Marilyn L.
腹裂在年轻女性的后代中特别普遍，近几十年来有所增加。虽然以前的研究表明，母亲饮酒与腹裂风险增加有关，但没有人探讨母亲年龄是否会改变这种关联。通过母亲年龄评估母亲自我报告的围受孕期饮酒（受孕前1个月至受孕后第3个月）与后代腹裂风险之间的相关性。我们使用了来自国家出生缺陷预防研究（NBDPS）的数据，这是一项基于多中心人群的病例对照研究。我们的分析包括1997-2011年在美国10个州分娩的1，450例腹裂病例和11，829例未受影响的活产对照。我们估计了饮酒和年轻产妇分娩年龄（<25岁vs. ≥25岁）对腹裂风险的个体和联合影响的调整后优势比（aOR）和95%置信区间（CI）。我们估计了相互作用引起的相对超额风险（RERI），以量化加性相互作用。无论母亲年龄如何，围产期饮酒都很常见（<25岁的女性：病例38.8%，对照组29.3%; ≥25岁的女性：病例43.5%，对照组39.5%）。与不饮酒的≥25岁女性相比，我们观察到<25岁女性腹裂的风险增加，饮酒女性的估计值更高（未饮酒的<25岁女性：aOR 5.90，95% CI 4.89，7.11;饮酒的<25岁女性：aOR 8.21，95% CI 6.69，10.07）。年龄≥25岁的女性饮酒与腹裂无关（aOR 1.12，95% CI 0.88，1.42）。这表明饮酒与母亲年龄之间存在超加性相互作用（RERI=2.19，95% CI 1.02，3.36）。围产期饮酒可能会不成比例地增加年轻母亲腹裂的风险。我们的研究结果支持在怀孕期间避免饮酒的公共卫生建议。
Gastroschisis is particularly prevalent among offspring of young women and has increased over recent decades. Although previous studies suggest that maternal alcohol consumption is associated with increased gastroschisis risk, none have explored whether maternal age modifies that association. To evaluate associations between self-reported maternal periconceptional alcohol consumption (one month prior through the third month after conception) and risk of gastroschisis among offspring, by maternal age. We used data from the National Birth Defects Prevention Study (NBDPS), a multi-site population-based case-control study. Our analysis included 1,450 gastroschisis cases and 11,829 unaffected liveborn controls delivered during 1997-2011 in ten US states. We estimated adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for the individual and joint effects of alcohol consumption and young maternal age at delivery (<25 years vs. ≥25 years) on gastroschisis risk. We estimated the relative excess risk due to interaction (RERI) to quantify additive interaction. Periconceptional alcohol consumption was common regardless of maternal age (women <25 years: cases 38.8%, controls 29.3%; women ≥25: cases 43.5%, controls 39.5%). Compared to women ≥25 years who did not consume alcohol, we observed increased risk of gastroschisis among women <25 years, with higher estimates among those who consumed alcohol (women <25 years who did not consume alcohol: aOR 5.90, 95% CI 4.89, 7.11; women <25 years who did consume alcohol: aOR 8.21, 95% CI 6.69, 10.07). Alcohol consumption among women ≥25 years was not associated with gastroschisis (aOR 1.12, 95% CI 0.88, 1.42). This suggests super-additive interaction between alcohol consumption and maternal age (RERI=2.19, 95% CI 1.02, 3.36). Periconceptional alcohol consumption may disproportionately increase risk of gastroschisis among young mothers. Our findings support public health recommendations to abstain from alcohol consumption during pregnancy.
登录
查看更多内容
影响因子：
3.8
作者：
Freitas, Amanda B.;Centofanti, Sandra F.;Brizot, Maria L.
通讯作者：
Brizot, Maria L.
DOI：
10.1002/bdra.23130
发表时间：
2013-04-01
影响因子：
--
作者：
Rittler, Monica;Vauthay, Liliana;Mazzitelli, Nancy
通讯作者：
Mazzitelli, Nancy
影响因子：
2.4
作者：
Dewberry, Lindel C.;Kalia, Nargis;Liechty, Kenneth W.
通讯作者：
Liechty, Kenneth W.
影响因子：
2.4
作者：
Clark, Reese H.;Sousa, John;Tolia, Veeral N.
通讯作者：
Tolia, Veeral N.
DOI：
10.1002/bdra.23292
发表时间：
2014-11-01
影响因子：
--
作者：
Conway, Kristin M. Caspers;Romitti, Paul A.;Richardson, Sandra D.
通讯作者：
Richardson, Sandra D.