Remembrance of weaning past: the seminal papers.

Remembrance of weaning past: the seminal papers.
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回忆断奶的过去:开创性的论文。

DOI:
10.1007/s00134-006-0338-8
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发表时间:
2006
影响因子:
38.9
通讯作者:
Tobin,MartinJ
Tobin,MartinJ
中科院分区:
医学1区
文献类型:
--
作者:
Tobin,MartinJ

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在过去的30年里,呼吸机脱机的方法发生了很大的变化。变化来自三个领域的研究:病理生理学,断奶预测测试和断奶技术。生理学研究阐明了断奶失败的机制。它还揭示了断奶成功的标志。通过更可靠的预测,在20世纪70年代断奶会很乏味的患者现在可以更快地断奶。断奶的故事提供了元科学的几个教训:创造力的重要性,提出异端问题,偶然发现,心理定势,交叉受精和早熟的危害。断奶研究也说明了库恩式的常态科学是如何统治任何领域的。要想在断奶方面实现下一个飞跃,就必须少花点时间在常规科学上,多花点时间在提出(和测试)特立独行的想法上。
The approach to ventilator weaning has changed considerably over the past 30 years. Change has resulted from research in three areas: pathophysiology, weaning-predictor testing, and weaning techniques. Physiology research illuminated the mechanisms of weaning failure. It also uncovered markers of weaning success. Through more reliable prediction, patients whose weaning would have been tedious in the 1970s are now weaned more rapidly. The weaning story offers several lessons in metascience: importance of creativity, the asking of heretical questions, serendipity, mental-set psychology, cross-fertilization, and the hazards of precocity. Weaning research also illustrates how Kuhnian normal (me-too) science dominates any field. Making the next quantum leap in weaning will depend on spending less time on normal science and more on the raising (and testing) of maverick ideas.
抗心律失常药物和活性代谢物的亲脂性和血浆蛋白结合对人体的临床影响
DOI: 10.1111/j.1749-6632.1984.tb14507.x
发表时间: 1984
影响因子: 5.2
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DOI: --
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影响因子: 9.1
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