Characterization of Vaginal Microbiota in Women With Recurrent Spontaneous Abortion That Can Be Modified by Drug Treatment.
Characterization of Vaginal Microbiota in Women With Recurrent Spontaneous Abortion That Can Be Modified by Drug Treatment.
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反复自然流产女性阴道微生物群的特征可以通过药物治疗来改变
DOI：
10.3389/fcimb.2021.680643
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发表时间：
2021
影响因子：
5.7
通讯作者：
Ying C
中科院分区：
文献类型：
--
作者：
Zhao F;Chen Y;Gao J;Wu M;Li C;Wang Z;Huang N;Cui L;Du M;Ying C
目的阴道菌群在复发性流产（RSA）中的作用尚不清楚。本研究的目的是探讨RSA患者阴道菌群的特点以及药物治疗对阴道菌群的影响。方法采用病例对照研究方法，选择非妊娠RSA患者，分为治疗组和药物治疗组。药物治疗的患者分为二甲双胍组、二甲双胍+阿司匹林组和其他药物组。有活产且从未经历过自然流产的健康女性入组对照组。RSA患者和健康女性的阴道微生物组特征以及药物治疗对微生物组的影响通过使用Illumina MiSeq平台对V3-V4区域进行16S rRNA基因测序来评估。结果接受RSA的女性的微生物丰度低于健康女性。与对照组相比，患者阴道微生物群中7个分类群（巨球菌属、Sneathia sanguinegens、假单胞菌属、鞘氨醇单胞菌属、红球菌属、伯克霍尔德氏菌属-卡瓦列里氏菌属-副伯克霍尔德氏菌属和棒状杆菌属_1）的相对丰度发生显著变化，这可能与RSA密切相关。药物治疗改变了RSA患者阴道微生物群落的组成。二甲双胍联合阿司匹林治疗显著增加了阴道乳杆菌属的相对丰度。在病人身上。结论阴道微生物群组成的改变可能与RSA有关，可以通过药物治疗来改变。二甲双胍联合阿司匹林对阴道乳酸菌的影响值得关注。
Objective The role of vaginal microbiota in recurrent spontaneous abortion (RSA) remains unknown. The purpose of this study was to investigate characteristics of vaginal microbiota and the effects of drug treatment on vaginal microbiota of patients with RSA. Methods A case-control study was performed, in which non-pregnant patients who experienced RSA were selected and divided into untreated and drug-treated groups. Drug-treated patients were subdivided into the metformin group, metformin plus aspirin group, and other drugs group. Healthy women who had live births and never experienced spontaneous abortion were enrolled in the control group. Characteristics of vaginal microbiomes of patients with RSA and healthy women and the impact of drug treatment on the microbiome was evaluated via 16S rRNA gene sequencing of the V3-V4 region using the Illumina MiSeq platform. Results Women who underwent RSA had lower microbial richness than healthy women. Compared to controls, the relative abundance of seven taxa (Megasphaera, Sneathia sanguinegens, Pseudomonas, Sphingomonas, Rhodococcus, Burkholderia- Caballeronia-Paraburkholderia, and Corynebacterium_1) in the patient’s vaginal microbiota changed significantly, which may be closely related to RSA. The composition of the vaginal microbial community in RSA patients was altered by drug treatment. Metformin combined with aspirin treatment significantly increased the relative abundance of vaginal Lactobacillus spp. in patients. Conclusion An altered vaginal microbiome composition might be associated with RSA, which could be modified by drug treatment. The effect of metformin combined with aspirin on vaginal Lactobacillus is worthy of attention.
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阴道营养不良增加了早产胎儿膜破裂，新生儿败血症的风险，并因红霉素而加剧。
影响因子：
9.3
作者：
Brown RG;Marchesi JR;Lee YS;Smith A;Lehne B;Kindinger LM;Terzidou V;Holmes E;Nicholson JK;Bennett PR;MacIntyre DA
通讯作者：
MacIntyre DA
影响因子：
6.4
作者：
Hickey RJ;Zhou X;Settles ML;Erb J;Malone K;Hansmann MA;Shew ML;Van Der Pol B;Fortenberry JD;Forney LJ
通讯作者：
Forney LJ
DOI：
10.1073/pnas.1502875112
发表时间：
2015-09-01
影响因子：
11.1
作者：
DiGiulio, Daniel B.;Callahan, Benjamin J.;Relman, David A.
通讯作者：
Relman, David A.
他汀类药物的使用，阴道微生物组和阴道阴道阴道蛋白介导的细胞毒性之间的关联。
影响因子：
3.7
作者：
Abdelmaksoud AA;Girerd PH;Garcia EM;Brooks JP;Leftwich LM;Sheth NU;Bradley SP;Serrano MG;Fettweis JM;Huang B;Strauss JF 3rd;Buck GA;Jefferson KK
通讯作者：
Jefferson KK
影响因子：
4.4
作者：
Harwich MD Jr;Serrano MG;Fettweis JM;Alves JM;Reimers MA;Vaginal Microbiome Consortium (additional members);Buck GA;Jefferson KK
通讯作者：
Jefferson KK