Effects of dietary carbohydrate replaced with wild rice (Zizania latifolia (Griseb) Turcz) on insulin resistance in rats fed with a high-fat/cholesterol diet.
Effects of dietary carbohydrate replaced with wild rice (Zizania latifolia (Griseb) Turcz) on insulin resistance in rats fed with a high-fat/cholesterol diet.
复制标题
用菰米（Zizania latifolia (Griseb) Turcz）替代膳食碳水化合物对高脂肪/胆固醇饮食大鼠胰岛素抵抗的影响
DOI：
10.3390/nu5020552
复制
发表时间：
2013-02-15
期刊：
影响因子：
5.9
通讯作者：
Zhai C
中科院分区：
文献类型：
--
作者：
Han S;Zhang H;Qin L;Zhai C
野生稻（WR）是一种非常有营养的谷物，在中医实践中被用于治疗糖尿病。城市饮食（CD）是以现代社会亚洲地区居民的饮食为基础，富含饱和脂肪、胆固醇和碳水化合物。本研究的目的是评价用WR替代CD的白色大米和加工小麦淀粉作为膳食碳水化合物的主要来源对高脂/高胆固醇饮食喂养的大鼠的胰岛素抵抗的影响。除低脂饮食组外，其余3组（高脂/高胆固醇饮食组、CD组和WR组）均给予高脂/高胆固醇饮食8周。与食用HFC饮食的大鼠相比，喂食CD的大鼠表现出更高的体重增加和更低的胰岛素敏感性。然而，WR抑制高脂肪/胆固醇饮食诱导的胰岛素抵抗。WR降低肝匀浆甘油三酯和游离脂肪酸水平，升高血清脂联素浓度，降低血清脂质运载蛋白2和内脂素浓度。此外，WR饮食有效地增加了脂联素受体2，过氧化物酶体增殖物激活受体，α和γ的相对表达，并减少了瘦素和脂质运载蛋白-2在感兴趣的组织中的相对表达。这些发现表明，WR对改善大鼠的异常葡萄糖代谢和胰岛素抵抗是有效的，即使当饮食中摄入的脂肪和胆固醇高。
Wild rice (WR) is a very nutritious grain that has been used to treat diabetes in Chinese medicinal practice. City diet (CD) is based on the diet consumed by Asian area residents in modern society, which is rich in saturated fats, cholesterol and carbohydrates. The present study was aimed at evaluating the effects of replacing white rice and processed wheat starch of CD with WR as the chief source of dietary carbohydrates on insulin resistance in rats fed with a high-fat/cholesterol diet. Except the rats of the low-fat (LF) diet group, the rats of the other three groups, including to high-fat/cholesterol (HFC) diet, CD and WR diet, were fed with high-fat/cholesterol diets for eight weeks. The rats fed with CD exhibited higher weight gain and lower insulin sensitivity compared to the rats consuming a HFC diet. However, WR suppressed high-fat/cholesterol diet-induced insulin resistance. WR decreased liver homogenate triglyceride and free fatty acids levels, raised serum adiponectin concentration and reduced serum lipocalin-2 and visfatin concentrations. In addition, the WR diet potently augmented the relative expressions of adiponectin receptor 2, peroxisome proliferator-activated receptors, alpha and gamma, and abated relative expressions of leptin and lipocalin-2 in the tissues of interest. These findings indicate that WR is effective in ameliorating abnormal glucose metabolism and insulin resistance in rats, even when the diet consumed is high in fat and cholesterol.
登录
查看更多内容
影响因子：
1.7
作者：
Azhar S
通讯作者：
Azhar S
影响因子：
5
作者：
de Kok, Theo M.;van Breda, Simone G.;Manson, Margaret M.
通讯作者：
Manson, Margaret M.
DOI：
10.1080/07315724.2002.10719227
发表时间：
2002-08-01
影响因子：
3.5
作者：
Liu, SM
通讯作者：
Liu, SM
影响因子：
6.1
作者：
Popkin BM;Adair LS;Ng SW
通讯作者：
Ng SW
影响因子：
8.2
作者：
MATTHEWS, DR;HOSKER, JP;TURNER, RC
通讯作者：
TURNER, RC