Association of plasminogen activator inhibitor-1 and tissue plasminogen activator with type 2 diabetes and metabolic syndrome in Malaysian subjects.
Association of plasminogen activator inhibitor-1 and tissue plasminogen activator with type 2 diabetes and metabolic syndrome in Malaysian subjects.
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马来西亚受试者中纤溶酶原激活剂-1和组织纤溶酶原激活剂与2型糖尿病和代谢综合征的组织相关。
DOI：
10.1186/1475-2840-10-23
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发表时间：
2011-03-18
影响因子：
9.3
通讯作者：
Muniandy S
中科院分区：
文献类型：
--
作者：
Al-Hamodi Z;Ismail IS;Saif-Ali R;Ahmed KA;Muniandy S
血浆纤溶酶原激活剂抑制剂-1 (PAI-1) 活性增加和组织纤溶酶原激活剂 (tPA) 活性降低可被认为是代谢综合征 (MetS) 的真正组成部分，与心血管疾病 (CVD) 和纤溶异常风险增加相关。本研究的目的是调查马来西亚 T2D 和正常受试者中 tPA 及其抑制剂 PAI-1 与 2 型糖尿病 (T2D) 和 MetS 的关联，以及 PAI-1 和 tPA 活性与抗原之间的相互关系。在 303 名 T2D 受试者（227 名患有 MetS 和 76 名无 MetS）、131 名正常非糖尿病非代谢受试者和 101 名非糖尿病 MetS 受试者中研究了 PAI-1 和 tPA 的血浆活性和抗原、tPA/PAI-1 复合物的水平以及血清胰岛素、冠脉风险小组参数和空腹状态下的血糖。与正常受试者相比，患有 MetS 的 T2D 受试者 (P = 9.8 × 10-19) 和患有 MetS 的非糖尿病受试者 (P = 3.0 × 10-15) 的 PAI-1 活性较高，而患有 MetS 的 T2D 受试者的 tPA 活性较低 (P = 0.003)。合并 MetS 的 T2D 受试者 (P = 8.9 × 10-24)、不合并 MetS 的 T2D 受试者 (P = 1.3 × 10-13) 和非糖尿病 MetS 受试者 (P = 0.002) 的血浆 tPA 抗原水平较高。正常人PAI-1活性及抗原水平与胰岛素抵抗相关(P=2.2×10-4;0.007)。此外，PAI-1 活性与腰围增加 (P = 2.2 × 10-4) 和 HDL-c 降低 (P = 0.005) 相关，而 tPA 活性与 FBG 降低相关 (P = 0.028)。糖尿病受试者中 PAI-1 活性与其抗原之间的相关性最高（R2 = 0.695，P = 1.1 × 10-36）。在正常受试者中，tPA 活性与其抗原呈负相关（R2 = -0.444，P = 7.7 × 10-13）；在糖尿病受试者中，tPA 活性与其抗原呈负相关（R2 = -0.319，P = 9.9 × 10-12；R2 = -0.228，P = 3.4 × 10-6）。 PAI-1 和 tPA 活性和抗原与马来西亚受试者的糖尿病和 MetS 参数相关。
Increased plasma plasminogen activator inhibitor-1 (PAI-1) activity and decreased tissue plasminogen activator (tPA) activity could be considered a true component of the metabolic syndrome (MetS) associated with an increased risk of developing cardiovascular diseases (CVD) and fibrinolytic abnormalities. The aim of this study was to investigate the association of tPA and its inhibitor PAI-1 with type 2 diabetes (T2D) and MetS and interrelationship between PAI-1and tPA activities and antigens in Malaysian T2D and normal subjects. The plasma activities and antigens of PAI-1 and tPA and the levels of the tPA/PAI-1 complex as well as serum insulin, parameter of the coronary risk panel and plasma glucose at fasting state were studied in 303 T2D subjects (227 with MetS and 76 without MetS), 131 normal non-diabetic non-metabolic subjects and 101 non-diabetic MetS subjects. The PAI-1 activity was higher in subjects with T2D with MetS (P = 9.8 × 10-19) and non-diabetic subjects with MetS (P = 3.0 × 10-15), whereas the tPA activity was lower in T2D with MetS (P = 0.003) as compare to normal subjects. Plasma tPA antigen levels were higher in subjects with T2D with MetS (P = 8.9 × 10-24), T2D without MetS (P = 1.3 × 10-13) and non-diabetic MetS subjects (P = 0.002). The activity and antigen of PAI-1 in normal subjects were related to insulin resistance (P = 2.2 × 10-4; 0.007). Additionally, the PAI-1 activity was associated with an increased waist circumference (P = 2.2 × 10-4) and decreased HDL-c (P = 0.005), whereas the tPA activity was associated with decreased FBG (P = 0.028). The highest correlation was between PAI-1 activity and its antigen (R2 = 0.695, P = 1.1 × 10-36) in diabetic subjects. The tPA activity negatively correlated with its antigen (R2 = -0.444, P = 7.7 × 10-13) in normal subjects and with the PAI-1 activity and antigen (R2 = -0.319, P = 9.9 × 10-12; R2 = -0.228, P = 3.4 × 10-6) in diabetic subjects. PAI-1 and tPA activities and antigens were associated with diabetes and MetS parameters in Malaysian subjects.
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DOI：
10.1161/atvbaha.107.151092
发表时间：
2008-04-01
影响因子：
8.7
作者：
Grundy, Scott M.
通讯作者：
Grundy, Scott M.
影响因子：
4.8
作者：
Hsia, J;Bittner, V;Howard, BV
通讯作者：
Howard, BV
DOI：
10.1161/01.atv.0000015445.22243.f4
发表时间：
2002-05-01
影响因子：
8.7
作者：
Juhan-Vague, I;Morange, PE;Humphries, SE
通讯作者：
Humphries, SE
影响因子：
7.7
作者：
Alexander, CM;Landsman, PB;Haffner, SM
通讯作者：
Haffner, SM
影响因子：
158.5
作者：
HAMSTEN, A;WIMAN, B;BLOMBACK, M
通讯作者：
BLOMBACK, M