Blood Oxygenation Level-Dependent MRI to Assess Renal Oxygenation in Renal Diseases: Progresses and Challenges.
Blood Oxygenation Level-Dependent MRI to Assess Renal Oxygenation in Renal Diseases: Progresses and Challenges.
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DOI：
10.3389/fphys.2016.00667
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发表时间：
2016
影响因子：
4
通讯作者：
Burnier M
中科院分区：
文献类型：
--
作者：
Pruijm M;Milani B;Burnier M
BOLD-MRI（血氧水平相关磁共振成像）可以对人体肾组织氧合进行无创测量，无需造影剂。 BOLD-MRI 利用血红蛋白的磁特性取决于其氧合状态的事实：局部脱氧血红蛋白越高，所谓的表观弛豫率 R2* (sec−1) 越高，局部组织氧含量越低。除脱氧血红蛋白外，还有几个因素（例如水合状态、膳食钠摄入量和敏感性影响）会影响 BOLD 信号，在解释结果时需要考虑这些因素。过去 5 年，这些因素的标准化取得了重要进展，并且出现了新的、高度可重复的 BOLD 图像分析技术，本文对此进行了综述。使用这些新的 BOLD-MRI 分析技术，最近表明，患有慢性肾脏疾病 (CKD) 的人的皮质氧合水平低于血压正常的对照者，从而证实了慢性缺氧假说。在 CKD 中，给予呋塞米后 R2* 的急性变化较小，代表了对钠依赖于氧的肾小管转运的估计。 BOLD-MRI（单独或与其他功能性 MRI 方法结合使用）可用于监测药物对肾脏的影响，并且越来越多地用于临床前环境。在不久的将来，我们将知道 BOLD-MRI 是否是预测肾功能衰退和不良肾脏结局的新工具。
BOLD-MRI (blood oxygenation-level dependent magnetic resonance imaging) allows non-invasive measurement of renal tissue oxygenation in humans, without the need for contrast products. BOLD-MRI uses the fact that magnetic properties of hemoglobin depend of its oxygenated state:: the higher local deoxyhemoglobin, the higher the so called apparent relaxation rate R2* (sec−1), and the lower local tissue oxygen content. Several factors other than deoxyhemoglobin (such as hydration status, dietary sodium intake, and susceptibility effects) influence the BOLD signal, and need to be taken into account when interpreting results. The last 5 years have witnessed important improvements in the standardization of these factors, and the appearance of new, highly reproducible analysis techniques of BOLD-images, that are reviewed in this article. Using these new BOLD-MRI analysis techniques, it has recently been shown that persons suffering from chronic kidney diseases (CKD) have lower cortical oxygenation than normotensive controls, thus confirming the chronic hypoxia hypothesis. The acute alterations in R2* after the administration of furosemide are smaller in CKD, and represent an estimate of the oxygen-dependent tubular transport of sodium. BOLD-MRI-alone or in combination with other functional MRI methods- can be used to monitor the renal effects of drugs, and is increasingly used in the preclinical setting. The near future will tell whether or not BOLD-MRI represents a new tool to predict renal function decline an adverse renal outcome.
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影响因子：
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作者：
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作者：
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发表时间：
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影响因子：
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