Metagenomic identification of a new sarbecovirus from horseshoe bats in Europe.
Metagenomic identification of a new sarbecovirus from horseshoe bats in Europe.
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DOI：
10.1038/s41598-021-94011-z
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发表时间：
2021-07-19
影响因子：
4.6
通讯作者：
Bell D
中科院分区：
文献类型：
--
作者：
Crook JM;Murphy I;Carter DP;Pullan ST;Carroll M;Vipond R;Cunningham AA;Bell D
COVID-19 大流行的来源尚不清楚，但 sarbeco 病毒的祖先被认为是亚洲马蹄蝠 (rhinolophid) 蝙蝠。我们从位于犀牛科动物分布范围最西端的英国马蹄蝠中鉴定出一种新型 sarbecovirus (RhGB01)，并对其进行了测序。我们的研究结果扩大了 sarbecoviruses 的地理范围和物种范围，并表明它们存在于整个马蹄蝠分布中。在刺突蛋白受体结合域内，但不包括受体结合基序，RhGB01 具有 77% (SARS-CoV-2) 和 81% (SARS-CoV) 氨基酸同源性。虽然 RhGB01 明显缺乏 hACE2 结合能力，因此在没有突变的情况下不太可能是人畜共患，但 RhGB01 为 SARS-CoV-2 和其他 sarbecovirus 同源重组提供了机会。我们的研究结果强调，sarbecoviruses 的自然分布和通过中间宿主共同感染进行重组的机会被低估了。对于当前针对该病毒的全球大规模疫苗接种活动而言，防止 SARS-CoV-2 传播给蝙蝠至关重要。
The source of the COVID-19 pandemic is unknown, but the natural host of the progenitor sarbecovirus is thought to be Asian horseshoe (rhinolophid) bats. We identified and sequenced a novel sarbecovirus (RhGB01) from a British horseshoe bat, at the western extreme of the rhinolophid range. Our results extend both the geographic and species ranges of sarbecoviruses and suggest their presence throughout the horseshoe bat distribution. Within the spike protein receptor binding domain, but excluding the receptor binding motif, RhGB01 has a 77% (SARS-CoV-2) and 81% (SARS-CoV) amino acid homology. While apparently lacking hACE2 binding ability, and hence unlikely to be zoonotic without mutation, RhGB01 presents opportunity for SARS-CoV-2 and other sarbecovirus homologous recombination. Our findings highlight that the natural distribution of sarbecoviruses and opportunities for recombination through intermediate host co-infection are underestimated. Preventing transmission of SARS-CoV-2 to bats is critical with the current global mass vaccination campaign against this virus.
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