Does insulin resistance influence neurodegeneration in non-diabetic Alzheimer's subjects?
Does insulin resistance influence neurodegeneration in non-diabetic Alzheimer's subjects?
复制标题
胰岛素抵抗是否会影响非糖尿病阿尔茨海默病受试者的神经变性？
DOI：
10.1186/s13195-021-00784-w
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发表时间：
2021-02-17
期刊：
影响因子：
--
通讯作者：
Edison P
中科院分区：
文献类型：
--
作者：
Femminella GD;Livingston NR;Raza S;van der Doef T;Frangou E;Love S;Busza G;Calsolaro V;Carver S;Holmes C;Ritchie CW;Lawrence RM;McFarlane B;Tadros G;Ridha BH;Bannister C;Walker Z;Archer H;Coulthard E;Underwood B;Prasanna A;Koranteng P;Karim S;Junaid K;McGuinness B;Passmore AP;Nilforooshan R;Macharouthu A;Donaldson A;Thacker S;Russell G;Malik N;Mate V;Knight L;Kshemendran S;Tan T;Holscher C;Harrison J;Brooks DJ;Ballard C;Edison P
2型糖尿病是阿尔茨海默病（AD）的危险因素，并且AD大脑显示受损的胰岛素信号传导。外周胰岛素抵抗在非糖尿病患者AD发病机制中的作用仍有争议。在这里，我们评估了胰岛素抵抗对非糖尿病AD患者脑葡萄糖代谢、灰质体积和白色病变（WML）的影响。总共有130名非糖尿病AD受试者接受了MRI和[18 F]FDG PET扫描，并插入动脉插管进行放射性测量。在3-T MRI扫描仪上获得T1容积和FLAIR序列。这些受试者在扫描当天禁食4小时后还测量了葡萄糖和胰岛素水平。通过更新的稳态模型评估（HOMA 2）计算胰岛素抵抗。对于[18 F]FDG分析，使用具有动脉血浆输入功能的频谱分析生成脑葡萄糖代谢率（rCMRGlc）参数图像。在该非糖尿病AD人群中，HOMA 2与海马rCMRGlc呈负相关，沿着总灰质体积。HOMA 2与海马体积和WML之间无显著相关性。在非糖尿病AD中，外周胰岛素抵抗与海马葡萄糖代谢降低和灰质体积降低独立相关，表明外周胰岛素抵抗可能通过其对脑葡萄糖代谢和神经变性的作用影响AD病理学。在线版本包含补充材料，可通过10.1186/s13195-021-00784-w获得。
Type 2 diabetes is a risk factor for Alzheimer’s disease (AD), and AD brain shows impaired insulin signalling. The role of peripheral insulin resistance on AD aetiopathogenesis in non-diabetic patients is still debated. Here we evaluated the influence of insulin resistance on brain glucose metabolism, grey matter volume and white matter lesions (WMLs) in non-diabetic AD subjects. In total, 130 non-diabetic AD subjects underwent MRI and [18F]FDG PET scans with arterial cannula insertion for radioactivity measurement. T1 Volumetric and FLAIR sequences were acquired on a 3-T MRI scanner. These subjects also had measurement of glucose and insulin levels after a 4-h fast on the same day of the scan. Insulin resistance was calculated by the updated homeostatic model assessment (HOMA2). For [18F]FDG analysis, cerebral glucose metabolic rate (rCMRGlc) parametric images were generated using spectral analysis with arterial plasma input function. In this non-diabetic AD population, HOMA2 was negatively associated with hippocampal rCMRGlc, along with total grey matter volumes. No significant correlation was observed between HOMA2, hippocampal volume and WMLs. In non-diabetic AD, peripheral insulin resistance is independently associated with reduced hippocampal glucose metabolism and with lower grey matter volume, suggesting that peripheral insulin resistance might influence AD pathology by its action on cerebral glucose metabolism and on neurodegeneration. The online version contains supplementary material available at 10.1186/s13195-021-00784-w.
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DOI：
10.1038/nrneurol.2017.185
发表时间：
2018-03
期刊：
Nature reviews. Neurology
影响因子：
--
作者：
Arnold SE;Arvanitakis Z;Macauley-Rambach SL;Koenig AM;Wang HY;Ahima RS;Craft S;Gandy S;Buettner C;Stoeckel LE;Holtzman DM;Nathan DM
通讯作者：
Nathan DM
影响因子：
5.6
作者：
Kimura N
通讯作者：
Kimura N
胰岛素与阿尔茨海默氏病和衰老的认知下降和萎缩有不同的关系。
DOI：
10.1016/j.bbadis.2011.06.011
发表时间：
2012-03
影响因子：
6.2
作者：
Burns, Jeffrey M.;Honea, Robyn A.;Vidoni, Eric D.;Hutfles, Lewis J.;Brooks, William M.;Swerdlow, Russell H.
通讯作者：
Swerdlow, Russell H.
影响因子：
16.2
作者：
Hill NR;Levy JC;Matthews DR
通讯作者：
Matthews DR
影响因子：
48
作者：
Cukierman-Yaffe, Tali;Gerstein, Hertzel C.;Temelkova-Kurktschiev, Theodora
通讯作者：
Temelkova-Kurktschiev, Theodora