Increased level of FAM19A5 is associated with cerebral small vessel disease and leads to a better outcome.
Increased level of FAM19A5 is associated with cerebral small vessel disease and leads to a better outcome.
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作者：
Hao Z;Yang S;Yin R;Wei J;Wang Y;Pan X;Ma A
FAM19A5在中枢神经系统的发育和急性或慢性炎症中起重要作用。本研究旨在探讨FAM19A5与脑小血管病（cSVD）的关系。共有344例近期小皮质下梗死（RSSI）患者和265名健康对照者被纳入本研究。比较两组间FAM19A5水平的差异，并分析FAM19A5与脑梗死体积的相关性。此外，还探讨了FAM19A5与总磁共振成像（MRI）负荷及其成像特征之间的关联。此外，通过Δ美国国立卫生研究院卒中量表评分（NIHSS）和NIHSS改善百分比评估FAM19A5与结局的对应性。FAM19A5在RSSI组中呈高表达（P = 0.023），与脑梗死体积呈正相关（P < 0.01）。与MRI总cSVD负荷呈正相关（P < 0.001），反映了白色高信号（WMH）（P < 0.01）和血管周围间隙扩大（EPVS）（P < 0.01）的严重程度，但与脑微出血（CMB）和腔隙无关。此外，FAM19A5显示更大的Δ NIHSS（P = 0.021）和NIHSS改善百分比（P = 0.007）。血清FAM19A5在RSSI中升高，并与梗死体积呈正相关。它还反映了cSVD的总MRI负荷，其中影像学特征与WMH和EPVS呈正相关。此外，更高的FAM19A5水平反映了RSSI患者的更好结果。
FAM19A5 plays an essential role in the development and acute or chronic inflammation of the central nervous system. The present study aimed to explore the association between FAM19A5 and cerebral small vessel disease (cSVD). A total of 344 recent small subcortical infarct (RSSI) patients and 265 healthy controls were included in this study. The difference in the FAM19A5 level between the two groups was compared and the correlation between FAM19A5 and cerebral infarction volume was analyzed. Also, the association between FAM19A5 and the total magnetic resonance imaging (MRI) burden with its imaging characteristics was explored. Moreover, the correspondence of FAM19A5 with the outcome was assessed via Δ National Institutes of Health Stroke Scale score (NIHSS) and the percentage of NIHSS improvement. FAM19A5 was highly expressed in the RSSI group (P = 0.023), showing a positive correlation with cerebral infarction volume (P < 0.01). It was positively correlated with total MRI cSVD burden (P < 0.001) and reflected the severity of white matter hyperintensity (WMH) (P < 0.01) and enlarged perivascular space (EPVS) (P < 0.01), but did not show any association with cerebral microbleed (CMB) and lacune. Moreover, FAM19A5 suggested a larger Δ NIHSS (P = 0.021) and NIHSS improvement percentage (P = 0.007). Serum FAM19A5 was increased in RSSI and positively correlated with the infarct volume. It also reflects the total MRI burden of cSVD, of which the imaging characteristics are positively correlated with WMH and EPVS. In addition, higher FAM19A5 levels reflect better outcomes in RSSI patients.
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DOI：
10.1159/000375153
发表时间：
2015
期刊：
Cerebrovascular diseases (Basel, Switzerland)
影响因子：
--
作者：
Potter GM;Chappell FM;Morris Z;Wardlaw JM
通讯作者：
Wardlaw JM
影响因子：
5.7
作者：
Bogiatzi, Chrysi;Wannarong, Thapat;Spence, J. David
通讯作者：
Spence, J. David
影响因子：
5
作者：
Janaway, B. M.;Simpson, J. E.;Ince, P. G.
通讯作者：
Ince, P. G.
影响因子：
5.9
作者：
Zhang, Haojie;Li, Zixiao;Wang, Yongjun
通讯作者：
Wang, Yongjun
DOI：
10.1038/nri2873
发表时间：
2010-12
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
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