Endothelial and circulating C19MC microRNAs are biomarkers of infantile hemangioma.
Endothelial and circulating C19MC microRNAs are biomarkers of infantile hemangioma.
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DOI：
10.1172/jci.insight.88856
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发表时间：
2016-09-08
期刊：
影响因子：
8
通讯作者：
Perkins JA
中科院分区：
文献类型：
--
作者：
Strub GM;Kirsh AL;Whipple ME;Kuo WP;Keller RB;Kapur RP;Majesky MW;Perkins JA
婴儿血管瘤（IH）是婴儿期最常见的血管肿瘤，口服普萘洛尔后，它会独特地消退。 MicroRNA (miRNA) 已成为血管发育的关键调节因子，并且在许多疾病过程中失调，但 miRNA 在 IH 生长中的作用尚未得到研究。我们报告了 C19MC 的表达，C19MC 是一种灵长类特异性 miRNA 巨簇，在胎盘中表达，但在产后组织、表达葡萄糖转运蛋白 1（表达 GLUT-1）的 IH 内皮细胞和 IH 儿童血浆中很少表达。在患有其他 9 种血管异常的患者或未受影响的儿童中，未检测到组织或循环 C19MC miRNA，因此将 C19MC miRNA 确定为 IH 的第一个循环生物标志物。循环 C19MC miRNA 的水平与 IH 肿瘤大小和普萘洛尔治疗反应相关，接受普萘洛尔治疗的儿童或肿瘤部分消退的儿童的 IH 组织中 C19MC miRNA 的水平低于未经治疗的增殖性肿瘤，这表明 C19MC miRNA 是 IH 发病机制的潜在驱动因素。检测患有 IH 的婴儿循环中的 C19MC miRNA 可能为 IH 诊断和识别普萘洛尔治疗候选者提供一种特异且无创的方法，以及监测治疗反应的方法。
Infantile hemangioma (IH) is the most common vascular tumor of infancy, and it uniquely regresses in response to oral propranolol. MicroRNAs (miRNAs) have emerged as key regulators of vascular development and are dysregulated in many disease processes, but the role of miRNAs in IH growth has not been investigated. We report expression of C19MC, a primate-specific megacluster of miRNAs expressed in placenta with rare expression in postnatal tissues, in glucose transporter 1–expressing (GLUT-1–expressing) IH endothelial cells and in the plasma of children with IH. Tissue or circulating C19MC miRNAs were not detectable in patients having 9 other types of vascular anomalies or unaffected children, identifying C19MC miRNAs as the first circulating biomarkers of IH. Levels of circulating C19MC miRNAs correlated with IH tumor size and propranolol treatment response, and IH tissue from children treated with propranolol or from children with partially involuted tumors contained lower levels of C19MC miRNAs than untreated, proliferative tumors, implicating C19MC miRNAs as potential drivers of IH pathogenesis. Detection of C19MC miRNAs in the circulation of infants with IH may provide a specific and noninvasive means of IH diagnosis and identification of candidates for propranolol therapy as well as a means to monitor treatment response.
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影响因子：
1.9
作者：
Keller, Rachel B.;El Demellawy, Dina;Kapur, Raj P.
通讯作者：
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DOI：
10.1158/1078-0432.ccr-14-1784
发表时间：
2014-12-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
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通讯作者：
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10.1016/j.bbrc.2012.05.004
发表时间：
2012-06-08
影响因子：
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通讯作者：
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影响因子：
30.8
作者：
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通讯作者：
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影响因子：
4.8
作者：
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通讯作者：
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