The Potential Role of Fatty Acids in Treating Diabetic Neuropathy.
The Potential Role of Fatty Acids in Treating Diabetic Neuropathy.
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DOI：
10.1007/s11892-018-1046-9
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发表时间：
2018-08-25
影响因子：
4.2
通讯作者：
Yorek MA
中科院分区：
文献类型：
--
作者：
Yorek MA
This review will summarize recent findings of the effect of supplemental fatty acids, with an emphasis on omega-3 polyunsaturated fatty acids, as a treatment for diabetic peripheral neuropathy. Pre-clinical studies have provided evidence that treating diabetic rodents with δ linolenic acid (omega-6 18:3) and to a greater extent with eicosapentaenoic and docosahexaenoic acids (omega-3 20:5 and 22:6, respectively) improve and even reverse vascular and neural deficits. Additional studies have shown resolvins, metabolites of eicosapentaenoic and docosahexaenoic acids, can induce neurite outgrowth in neuron cultures and that treating type 1 or type 2 diabetic mice with resolvin D1 or E1 provides benefit for peripheral neuropathy similar to fish oil. Omega-3 polyunsaturated fatty acids derived from fish oil and their derivatives have anti-inflammatory properties and could provide benefit for diabetic peripheral neuropathy. However, clinical trials are needed to determine whether this statement is true.
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影响因子：
4.3
作者：
Davidson EP;Coppey LJ;Shevalye H;Obrosov A;Yorek MA
通讯作者：
Yorek MA
DOI：
10.1056/nejmoa1001288
发表时间：
2010-07-15
期刊：
The New England journal of medicine
影响因子：
--
作者：
ACCORD Study Group;ACCORD Eye Study Group;Chew EY;Ambrosius WT;Davis MD;Danis RP;Gangaputra S;Greven CM;Hubbard L;Esser BA;Lovato JF;Perdue LH;Goff DC Jr;Cushman WC;Ginsberg HN;Elam MB;Genuth S;Gerstein HC;Schubart U;Fine LJ
通讯作者：
Fine LJ
影响因子：
4.2
作者：
Dobrowsky RT
通讯作者：
Dobrowsky RT
影响因子：
4.2
作者：
Gerbi, A;Maixent, JM;Raccah, D
通讯作者：
Raccah, D
影响因子：
2.5
作者：
Coppey, Lawrence J.;Davidson, Eric P.;Yorek, Mark A.
通讯作者：
Yorek, Mark A.