Examining Associations Between Amygdala Volumes and Anxiety Symptoms in Autism Spectrum Disorder.
Examining Associations Between Amygdala Volumes and Anxiety Symptoms in Autism Spectrum Disorder.
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DOI：
10.1016/j.bpsc.2021.10.010
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发表时间：
2022-09
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--
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焦虑是自闭症谱系障碍患者最常见的共生症状之一。杏仁核已被确认为与自闭症患者和非自闭症患者的焦虑有关，然而，自闭症的关联是基于相对较小或发育受限的样本，留下了这样的问题：这些结果是否适用于不同发育年龄和更大、更强大的样本。结构神经成像和焦虑症状的父母报告来自马里兰大学和自闭症脑成像数据交换中心的三个站点，5-13岁的自闭症儿童(n=123)和非自闭症儿童(n=171)的焦虑症状的父母报告来自马里兰大学和三个网站。计算了双侧杏仁核体积的标准化残差，调整了部位、半球体积和协变量(年龄、性别、全程智商)。临床上显著的焦虑症状不能区分不同组的杏仁核体积(即自闭症和焦虑症、自闭症无焦虑、无自闭症或焦虑症)。在自闭症患者的样本中，没有观察到左右杏仁核体积和焦虑评分之间的显著关联。荟萃分析和贝叶斯因子估计为零假设提供了额外的支持。年龄、性别和自闭症的严重程度并没有缓和焦虑和杏仁核体积之间的联系。在研究这一问题的最大样本中，没有观察到自闭症儿童的杏仁核体积与焦虑症状之间的关系。我们讨论了未来研究的方向，以确定包括年龄或评估方法在内的其他因素是否可能导致这种联系的缺乏。
Anxiety is one of the most common co-occurring conditions in people with autism spectrum disorder. The amygdala has been identified as related to anxiety in populations with and without autism, yet associations in autism were based on relatively small or developmentally constrained samples, leaving questions as to whether these results hold at different developmental ages and in a larger, more robust sample. Structural neuroimaging and parent report of anxiety symptoms of children aged 5 to 13 with (n = 123) and without (n = 171) a diagnosis of autism were collected from the University of Maryland and three sites from the Autism Brain Imaging Data Exchange. Standardized residuals for bilateral amygdala volumes were computed adjusting for site, hemispheric volumes, and covariates (age, sex, Full Scale Intelligence Quotient). Clinically significant anxiety symptoms did not differentiate amygdala volumes between groups (i.e., autism and anxiety, autism without anxiety, without autism or anxiety). No significant association between left or right amygdala volumes and anxiety scores was observed among the sample of individuals with autism. Meta-analytic and Bayes Factor estimations provided additional support for the null hypothesis. Age, sex, and autism severity did not moderate associations between anxiety and amygdala volumes. No relation between amygdala volumes and anxiety symptoms in children with autism was observed in the largest sample to investigate this question. We discuss directions for future research to determine whether additional factors including age or method of assessment may contribute to this lack of association.
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影响因子：
2.6
作者：
Dziobek, Isabel;Fleck, Stefan;Convit, Antonio
通讯作者：
Convit, Antonio
DOI：
10.1016/b978-0-12-391924-3.00021-1
发表时间：
2013-01-01
期刊：
NEUROSCIENCE OF AUTISM SPECTRUM DISORDERS
影响因子：
--
作者：
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通讯作者：
Hof, Patrick R.
DOI：
10.15585/mmwr.ss6706a1
发表时间：
2018-04-27
期刊：
Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002)
影响因子：
--
作者：
Baio J;Wiggins L;Christensen DL;Maenner MJ;Daniels J;Warren Z;Kurzius-Spencer M;Zahorodny W;Robinson Rosenberg C;White T;Durkin MS;Imm P;Nikolaou L;Yeargin-Allsopp M;Lee LC;Harrington R;Lopez M;Fitzgerald RT;Hewitt A;Pettygrove S;Constantino JN;Vehorn A;Shenouda J;Hall-Lande J;Van Naarden Braun K;Dowling NF
通讯作者：
Dowling NF
DOI：
10.1097/00004583-199704000-00018
发表时间：
1997-04-01
影响因子：
13.3
作者：
Birmaher, B;Khetarpal, S;Neer, SM
通讯作者：
Neer, SM
影响因子：
10.6
作者：
Gilpin NW;Herman MA;Roberto M
通讯作者：
Roberto M