Changes in Cardiometabolic Risk Factors Before and After Gestational Diabetes: A Prospective Life-Course Analysis in CARDIA Women.
Changes in Cardiometabolic Risk Factors Before and After Gestational Diabetes: A Prospective Life-Course Analysis in CARDIA Women.
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DOI：
10.1002/oby.22848
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发表时间：
2020-08
期刊：
影响因子：
--
通讯作者：
Gunderson EP
中科院分区：
文献类型：
--
作者：
Catov JM;Sun B;Bertolet M;Snyder GG;Lewis CE;Allen NB;Shikany JM;Ingram KH;Appiah D;Gunderson EP
我们假设妊娠期糖尿病（GDM）妇女与非GDM妇女相比，孕前和产后心脏代谢危险因素的模式可能不同。在1 302人中在年轻成人冠状动脉风险发展研究中，我们对51%的黑人女性进行了30年的随访，（BMI、腰围[WC]、脂质，血压）（基线后首次分娩前）和生育后期（最后一次出生后）的GDM状态使用分段线性混合模型调整社会人口统计学，奇偶性和随时间变化的协变量。与未发生GDM的女性相比，发生GDM的女性（n=152，12%）的体重和WC增加更快（BMI差异每年+0.12 kg/m2 [p=0.04]; WC差异每年+0.28 cm [p=0.04]），解释了协变量。这意味着，与非GDM分娩相比，随后GDM分娩的妇女在4年内平均体重增加1.3 kg。相反，生育后的斜率没有GDM状态的差异，也没有其他心脏代谢的差异。妊娠期糖尿病妇女孕前体重增加和中心性肥胖增加。GDM患者的绝对产后体重也较高，但GDM后体重增加的斜率却没有增加。
We hypothesized that both preconception and post-childbearing patterns of cardiometabolic risk factors may be different for women with gestational diabetes (GDM) compared to women without GDM. Among 1,302 (51% Black) women in the Coronary Artery Risk Development in Young Adults study with births and followed for 30 years, we evaluated changes in cardiometabolic factors (BMI, waist circumference [WC], lipids, blood pressure) during pre-childbearing (prior to the first post-baseline birth) and post-childbearing periods (after the last birth) by GDM status using piecewise linear mixed-models adjusted for socio-demographics, parity and time-varying covariates. Compared to women who did not develop GDM, weight and WC increases in women who developed GDM (n=152, 12%) were faster (BMI difference +0.12 kg/m2 per year [p=0.04]; WC difference +0.28 cm per year [p=0.04]) during the pre-childbearing period, accounting for covariates. This translated to an average of 1.3 kg excess weight gain across 4 years among women with subsequent GDM vs. non-GDM births. In contrast, slopes after childbearing did not differ by GDM status nor were there other cardiometabolic differences. Women with GDM exhibited an increasing pre-pregnancy pattern of weight gain and central adiposity. Absolute post-childbearing weight was also higher in GDM-affected women but the slope of gain after GDM was not.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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影响因子：
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DOI：
10.1016/j.numecd.2013.12.010
发表时间：
2014-06-01
影响因子：
3.9
作者：
Sijtsma, F. P. C.;Meyer, K. A.;Jacobs, D. R., Jr.
通讯作者：
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