Pediatric asthma incidence rates in the United States from 1980 to 2017.
Pediatric asthma incidence rates in the United States from 1980 to 2017.
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DOI：
10.1016/j.jaci.2021.04.027
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发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Children’s Respiratory and Environmental Workgroup in the ECHO Consortium
中科院分区：
文献类型：
--
作者：
Johnson CC;Havstad SL;Ownby DR;Joseph CLM;Sitarik AR;Biagini Myers J;Gebretsadik T;Hartert TV;Khurana Hershey GK;Jackson DJ;Lemanske RF Jr;Martin LJ;Zoratti EM;Visness CM;Ryan PH;Gold DR;Martinez FD;Miller RL;Seroogy CM;Wright AL;Gern JE;Children’s Respiratory and Environmental Workgroup in the ECHO Consortium
很少有研究从公共卫生监测的角度来研究纵向哮喘发病率。考虑人口统计学和父母哮喘史，计算儿童随时间推移的描述性哮喘发病率。来自9个美国出生队列的数据汇总到一个涵盖1980-2017年的人群中。结果是父母最早报告医生诊断为哮喘。计算每1,000人-年的发病率。6,283名儿童中，55%为欧洲裔美国人（EA），25.5%为非洲裔美国人（AA），9.5%为墨西哥裔西班牙裔美国人（MA），8.5%为加勒比裔西班牙裔美国人（CA）。平均随访时间为10.4年（SD=8.5年，中位数=8.4），总计65，291人-年，1789例哮喘诊断产生的粗发病率为27.5/1000人-年（95%CI 26.3-28.8）。0-4岁儿童中，特别是1995-1999年，特定年龄组的发病率最高，2000-2004年EA/MA下降，2010-2014年AA/CA下降。父母哮喘史与统计学显著增加的发生率相关。AA和CA的发病率相似且较高，而EA和MA的发病率较低但相似。从出生到青春期的性别比率差异主要是由于男性比率下降，但女性比率相对稳定。美国儿童哮喘发病率因年龄、性别、父母哮喘史、种族和日历年而差异显著。0-4岁儿童的发病率较高，特别是有双亲病史的AA/CA男性，以及发病率随时间和人口统计学因素的变化，表明哮喘是由遗传易感性与时间依赖性环境和社会因素变化之间的复杂相互作用驱动的。儿童哮喘发病率因出生年代、年龄、人种/种族、儿童性别、地区和父母病史而异。这些变化在0-4岁儿童中最为显著，表明环境和社会对遗传性哮喘倾向有很强的影响。
Few studies have examined longitudinal asthma incidence rates from a public health surveillance perspective. Calculate descriptive asthma incidence rates in children over time considering demographics and parental asthma history. Data from nine US birth cohorts were pooled into one population covering 1980-2017. The outcome was earliest parental report of a doctor diagnosis of asthma. Incidence rates per 1,000 person-years were calculated. The 6,283 children were 55% European-American (EA), 25.5% African-American (AA), 9.5% Mexican-Hispanic American (MA) and 8.5% Caribbean-Hispanic American (CA). Average follow-up was 10.4 years (SD=8.5 years, median=8.4) totaling 65,291 person-years, with 1789 asthma diagnoses yielding a crude incidence rate of 27.5 per 1000 person-years (95% CI 26.3-28.8). Age-specific rates were highest among children 0-4 years, notably from 1995-1999, with a decline in EA/MAs in 2000-2004 followed by a decline in AA/CAs in 2010-2014. Parental asthma history was associated with statistically significantly increased rates. Incidence rates were similar and higher in AA and CA compared to lower but similar rates in EA and MA. Differential rates by sex from birth through adolescence principally resulted from a decline in male but relatively stable female rates. US childhood asthma incidence rates varied dramatically by age, sex, parental asthma history, race and calendar year. Higher rates in the 0-4 year-olds, particularly in AA/CA males with a parental history, and changes in rates over time and by demographic factors, suggests that asthma is driven by complex interactions between genetic susceptibility and variation in time-dependent environmental and social factors. Childhood asthma incidence rates varied by decade of birth, age, race/ethnicity, child sex, region and parental history. These changes, most notable in children 0-4 years old, suggest strong environmental and societal influences on genetic asthma propensity.
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影响因子：
4.4
作者：
Engelkes, Marjolein;Janssens, Hettie M.;Verhamme, Katia M. C.
通讯作者：
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