Incidence of asthma and mortality in a cohort of young adults: a 7-year prospective study.
Incidence of asthma and mortality in a cohort of young adults: a 7-year prospective study.
复制标题
一群年轻人的哮喘和死亡率发生率：一项为期7年的前瞻性研究。
DOI：
10.1186/1465-9921-6-95
复制
发表时间：
2005-08-16
影响因子：
5.8
通讯作者：
Marinoni, A
中科院分区：
文献类型：
--
作者：
de Marco, R;Locatelli, F;Cazzoletti, L;Bugianio, M;Carosso, A;Marinoni, A
关于年轻成人哮喘发病率和哮喘导致的总体死亡风险的纵向数据很少。一项为期7年的前瞻性随访研究评估了一组年轻成人的哮喘发病率和各种原因的死亡率。1999年确定了6031名年龄在20-44岁之间的受试者的生活状况，这些受试者在1991年至1992年期间回答了呼吸筛查问卷。一份新的调查哮喘病史的问卷随后被发送给5236名仍然活着的研究对象和研究区域的居民。3880名受试者（74%）回答了第二份问卷。成人发病哮喘的发病率为15.3/10,000/年（95%CI: 11.2-20.8）。基线时哮喘样症状（IRR:4.17; 95%CI: 2.20-7.87）和变应性鼻炎（IRR:3.30; 95%CI: 1.71-6.36）的存在是哮喘发病的独立预测因子，其中女性更常见（IRR:2.32; 95%CI: 1.16-4.67），并且在年轻一代中增加。在基线时报告哮喘发作或夜间哮喘症状的受试者在随后的7年中因各种原因导致的死亡风险过高（SMR = 2.05; 95%CI: 1.06-3.58）。高死亡率主要是由于与呼吸系统疾病无关的原因。即使在年轻人中，哮喘的发生也是一个相关的公共卫生问题。患有变应性鼻炎的人、女性和最近几代人患成人哮喘的可能性要高得多。哮喘发作和夜间症状的出现似乎与全因死亡率的潜在超额风险有关。
Few longitudinal data exist on the incidence of asthma in young adults and on the overall mortality risk due to asthma. A 7-year follow-up prospective study was performed to assess the incidence of asthma and mortality from all causes in a cohort of young adults. The life status of a cohort of 6031 subjects, aged 20–44 years, who replied to a respiratory screening questionnaire between 1991 and 1992, was ascertained in 1999. A new questionnaire investigating the history of asthma was subsequently sent to the 5236 subjects who were still alive and residents in the areas of the study. 3880 subjects (74%) replied to the second questionnaire. The incidence of adult-onset asthma was 15.3/10,000/year (95%CI:11.2–20.8). The presence of asthma-like symptoms (IRR:4.17; 95%CI:2.20–7.87) and allergic rhinitis (IRR:3.30; 95%CI:1.71–6.36) at baseline were independent predictors of the onset of asthma, which was more frequent in women (IRR:2.32; 95%CI:1.16–4.67) and increased in the younger generations. The subjects who reported asthma attacks or nocturnal asthma symptoms at baseline had an excess mortality risk from all causes (SMR = 2.05; 95%CI:1.06–3.58) in the subsequent seven years. The excess mortality was mainly due to causes not related to respiratory diseases. Asthma occurrence is a relevant public health problem even in young adults. The likelihood of developing adult onset asthma is significantly higher in people suffering from allergic rhinitis, in women and in more recent generations. The presence of asthma attacks and nocturnal symptoms seems to be associated with a potential excess risk of all causes mortality.
登录
查看更多内容
DOI：
10.1164/ajrccm.164.7.2012143
发表时间：
2001-10-01
影响因子：
24.7
作者：
Basagaña, X;Sunyer, J;Antó, JM
通讯作者：
Antó, JM
影响因子：
10
作者：
Huovinen, E;Kaprio, J;Koskenvuo, M
通讯作者：
Koskenvuo, M
影响因子：
14.2
作者：
Lack, G
通讯作者：
Lack, G
影响因子：
168.9
作者：
Lange, P;Ulrik, CS;Vestbo, J
通讯作者：
Vestbo, J
影响因子：
10
作者：
LARSSON, L
通讯作者：
LARSSON, L