WISE 2005: stroke volume changes contribute to the pressor response during ischemic handgrip exercise in women.
WISE 2005: stroke volume changes contribute to the pressor response during ischemic handgrip exercise in women.
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WISE 2005：每搏输出量的变化有助于女性缺血性握力训练期间的升压反应。
DOI：
10.1152/japplphysiol.01334.2006
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发表时间：
2007
影响因子：
3.3
通讯作者：
R. Hughson
中科院分区：
文献类型：
--
作者：
J. Shoemaker;L. Mattar;P. Kerbeci;S. Trotter;P. Arbeille;R. Hughson
在小肌肉群(如前臂)运动和代谢性反射激活期间，升压反应的机制可能包括心输出量(Q)或总外周阻力(TPR)的升高。Q的增加必须由内脏静脉容量的减少来支持，以维持随着心率(HR)增加的静脉回流。因此，这项研究验证了内脏体积减少(门静脉收缩)支持的Q增加解释握力训练和代谢性反射激活时的升压反应的假说。17名健康女性分别进行2min的静态缺血握力运动和2min的运动后循环阻断(PECO)，测量心率、每搏输出量和股浅动脉血流(多普勒)、血压(Fineter)、门静脉内径(B超)和肌交感神经活动(MSNA；显微神经学)，计算Q、TPR和小腿血管阻力(LVR)。与基线相比，平均动脉压(MAP)(P<；0.001)和Q(P<；0.001)在每分钟的运动中都有所增加，同时门静脉内径减少了约5%(P<；0.05)。MAP在PECO期间保持升高，而Q下降到运动水平以下。MSNA在运动第二分钟和PECO期间均高于基线(P<；0.05)。在运动和PECO期间，TPR和LVR均未发生改变。数据表明，女性对等长握力运动的大多数血压反应是由于中心血容量的动员和每搏量和Q的增加，而不是TVR或LVR阻力的升高。
The mechanism of the pressor response to small muscle mass (e.g., forearm) exercise and during metaboreflex activation may include elevations in cardiac output (Q) or total peripheral resistance (TPR). Increases in Q must be supported by reductions in visceral venous volume to sustain venous return as heart rate (HR) increases. Therefore, this study tested the hypothesis that increases in Q, supported by reductions in splanchnic volume (portal vein constriction), explain the pressor response during handgrip exercise and metaboreflex activation. Seventeen healthy women performed 2 min of static ischemic handgrip exercise and 2 min of postexercise circulatory occlusion (PECO) while HR, stroke volume and superficial femoral artery flow (Doppler), blood pressure (Finometer), portal vein diameter (ultrasound imaging), and muscle sympathetic nerve activity (MSNA; microneurography) were measured followed by the calculation of Q, TPR, and leg vascular resistance (LVR). Compared with baseline, mean arterial blood pressure (MAP) (P < 0.001) and Q (P < 0.001) both increased in each minute of exercise accompanied by a approximately 5% reduction in portal vein diameter (P < 0.05). MAP remained elevated during PECO, whereas Q decreased below exercise levels. MSNA was elevated above baseline during the second minute of exercise and through the PECO period (P < 0.05). Neither TPR nor LVR was changed from baseline during exercise and PECO. The data indicate that the majority of the blood pressure response to isometric handgrip exercise in women was due to mobilization of central blood volume and elevated stroke volume and Q rather than elevations in TVR or LVR resistance.
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DOI：
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