Neurodevelopmental Trajectories in Children With Internalizing, Externalizing and Emotion Dysregulation Symptoms.
Neurodevelopmental Trajectories in Children With Internalizing, Externalizing and Emotion Dysregulation Symptoms.
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DOI：
10.3389/fpsyt.2022.846201
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发表时间：
2022
影响因子：
4.7
通讯作者：
White T
中科院分区：
文献类型：
--
作者：
Blok E;Geenjaar EPT;Geenjaar EAW;Calhoun VD;White T
童年和青春期是大脑和行为发育的关键时期。然而，目前尚不清楚如何以及何时偏离典型的大脑发育与精神病理学的广泛领域有关。使用基于人群的R代研究样本中的三波神经成像数据，跨越6 - 16岁的总年龄范围，我们应用规范建模来建立37个脑区（亚）皮质体积和32个脑区皮质厚度的典型发育曲线。提取代表偏离典型发育的Z分数，并将其与内化、外化和失调特征（DP）症状相关。规范建模显示发展轨迹的区域差异。精神病理学症状与皮质和皮质下广泛区域皮质体积典型发育的负偏差相关，与皮质眶额、额极、枕叶周围和后扣带回区域皮质厚度典型发育的正偏差相关。综上所述，本研究绘制了大脑（亚）皮质体积和皮质厚度的发育曲线。我们的研究结果表明，精神病理学症状与大脑发育的广泛差异有关，其中DP症状受影响最严重。
Childhood and adolescence are crucial periods for brain and behavioral development. However, it is not yet clear how and when deviations from typical brain development are related to broad domains of psychopathology. Using three waves of neuroimaging data within the population-based Generation R Study sample, spanning a total age range of 6–16 years, we applied normative modeling to establish typical development curves for (sub-)cortical volume in 37 brain regions, and cortical thickness in 32 brain regions. Z-scores representing deviations from typical development were extracted and related to internalizing, externalizing and dysregulation profile (DP) symptoms. Normative modeling showed regional differences in developmental trajectories. Psychopathology symptoms were related to negative deviations from typical development for cortical volume in widespread regions of the cortex and subcortex, and to positive deviations from typical development for cortical thickness in the orbitofrontal, frontal pole, pericalcarine and posterior cingulate regions of the cortex. Taken together, this study charts developmental curves across the cerebrum for (sub-)cortical volume and cortical thickness. Our findings show that psychopathology symptoms, are associated with widespread differences in brain development, in which those with DP symptoms are most heavily affected.
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DOI：
10.1111/jcpp.12895
发表时间：
2018-09
期刊：
Journal of child psychology and psychiatry, and allied disciplines
影响因子：
--
作者：
Bos MGN;Peters S;van de Kamp FC;Crone EA;Tamnes CK
通讯作者：
Tamnes CK
影响因子：
3.7
作者：
Ducharme, Simon;Albaugh, Matthew D.;Karama, Sherif
通讯作者：
Karama, Sherif
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
5.7
作者：
Fischl, Bruce
通讯作者：
Fischl, Bruce
前扣带皮层到腹侧海马回路介导情境恐惧泛化
影响因子：
5.3
作者：
Bian, Xin-Lan;Qin, Cheng;Zhu, Dong-Ya
通讯作者：
Zhu, Dong-Ya