Expression of P2X receptors on immune cells in the rat liver during postnatal development
Expression of P2X receptors on immune cells in the rat liver during postnatal development
复制标题
出生后发育过程中大鼠肝脏免疫细胞P2X受体的表达
DOI：
10.1007/s00418-006-0180-7
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发表时间：
2006-04
期刊：
影响因子：
--
通讯作者：
Burnstock G
中科院分区：
文献类型：
--
作者：
Xiang Z（向正华）;Lv J;Jiang P;Chen C;Jiang B;Burnstock G
Single and double-labeling immunofluorescence and RT-PCR expression of P2X receptor proteins and mRNAs were used in a study of the liver of postnatal rats. OX62 and ED1 were used as markers for dendritic and macrophage (Kupffer) cells respectively. The results showed that the P2X6receptor subunit was up-regulated by 15-fold on hepatic sinusoid cells during postnatal days P1 to P60. Subpopulations of Kupffer cells co-expressed P2X4and P2X6receptor subunits and dendritic cells co-expressed P2X4and P2X7receptor subunits. Lipopolysaccharide (endotoxin) injected into the peritoneal cavity led to increased expression of the P2X6receptor on Kupffer cells, suggesting that the P2X6receptor subunit may be up-regulated by endotoxin. This study presents the first evidence that P2X receptors are widely distributed in the rat liver immune system and that activation of Kupffer and dendritic cells in the rat liver might be regulated by extracellular ATP.
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P2X 受体亚基的异源寡聚体组装。
DOI：
10.1074/jbc.274.10.6653
发表时间：
1999
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Torres,GE;Egan,TM;Voigt,MM
通讯作者：
Voigt,MM
影响因子：
3.6
作者：
T. Sato;H. Yamamoto;C. Sasaki;K. Wake
通讯作者：
T. Sato;H. Yamamoto;C. Sasaki;K. Wake
影响因子：
21.1
作者：
V. Ralevic;G. Burnstock
通讯作者：
V. Ralevic;G. Burnstock
影响因子：
4.7
作者：
Collo, G;Neidhart, S;Buell, G
通讯作者：
Buell, G
DOI：
10.1152/ajpregu.00223.2005
发表时间：
2005-08
期刊：
American journal of physiology. Regulatory, integrative and comparative physiology
影响因子：
--
作者：
A. Steiner;S. Chakravarty;J. Robbins;Alexander S. Dragic;Jennifer Pan;M. Herkenham;A. A. Romanovsky-A.
通讯作者：
A. Steiner;S. Chakravarty;J. Robbins;Alexander S. Dragic;Jennifer Pan;M. Herkenham;A. A. Romanovsky-A.