Induction of transcriptional activity of AP-1 and NF-kappaB in the gastric mucosa during aging.
Induction of transcriptional activity of AP-1 and NF-kappaB in the gastric mucosa during aging.
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衰老过程中胃粘膜中 AP-1 和 NF-κB 转录活性的诱导。
DOI：
10.1152/ajpgi.2000.278.6.g855
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Majumdar,AP
中科院分区：
文献类型：
--
作者：
Xiao,ZQ;Majumdar,AP
虽然衰老增强了胃粘膜表皮生长因子受体（EGFR）的表达和酪氨酸激酶活性，但没有关于EGFR信号级联的信息。我们检测了4- 6岁、12- 14岁和22- 24岁Fischer 344大鼠胃粘膜中丝裂原活化蛋白激酶（MAPKs）[细胞外信号相关激酶（ERKs）、c-Jun nh2末端激酶（JNKs）和p38]、egfr诱导的信号级联以及激活蛋白1 （AP-1）和核因子-κ b （NF-κ b）转录活性的年龄相关变化。胃黏膜AP-1和NF-κB转录活性随年龄增长而稳步上升。转化生长因子-α可进一步诱导。胃黏膜AP-1和NF-κB的年龄相关激活与c-Jun、c-Fos和p52水平升高有关，但与p50或p65水平升高无关。胃黏膜总i - κ b α和磷酸化i - κ b α水平不受衰老影响。衰老还与ERKs （p42/p44）和JNK1的显著激活有关。相反，衰老降低胃黏膜p38 MAPK活性。我们观察到衰老大鼠胃粘膜中ERKs和JNK1的激活增加，这表明这些MAPKs可能调节AP-1和NF-κB的转录活性。这些事件可能是与年龄相关的胃粘膜增殖活性升高的原因。
Although aging enhances expression and tyrosine kinase activity of epidermal growth factor receptor (EGFR) in the gastric mucosa, there is no information about EGFR signaling cascades. We examined the age-related changes in mitogen-activated protein kinases (MAPKs) [extracellular signal-related kinases (ERKs), c-Jun NH2-terminal kinases (JNKs), and p38], an EGFR-induced signaling cascade, and activator protein-1 (AP-1) and nuclear factor-κB (NF-κB) transcriptional activity in the gastric mucosa of 4- to 6-, 12- to 14-, and 22- to 24-mo-old Fischer 344 rats. AP-1 and NF-κB transcriptional activity in the gastric mucosa rose steadily with advancing age. This can be further induced by transforming growth factor-α. The age-related activation of AP-1 and NF-κB in the gastric mucosa was associated with increased levels of c-Jun, c-Fos, and p52, but not p50 or p65. Total and phosphorylated IκBα levels in the gastric mucosa were unaffected by aging. Aging was also associated with marked activation of ERKs (p42/p44) and JNK1. In contrast, aging decreased p38 MAPK activity in the gastric mucosa. Our observation of increased activation of ERKs and JNK1 in the gastric mucosa of aged rats suggests a role for these MAPKs in regulating AP-1 and NF-κB transcriptional activity. These events may be responsible for the age-related rise in gastric mucosal proliferative activity.
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大鼠衰老过程中胃粘膜酪氨酸激酶活性及其与细胞增殖的关系。
DOI：
10.1016/0304-4165(88)90043-8
发表时间：
1988
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
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Elizabeth A. Edgerton
影响因子：
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DOI：
10.1152/ajpgi.1997.273.2.g389
发表时间：
1997
期刊：
The American journal of physiology.
影响因子：
--
作者：
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Majumdar,AP
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影响因子：
29.4
作者：
Y. Kinoshita;H. Nakata;S. Hassan;M. Asahara;C. Kawanami;Y. Matsushima;Y. Naribayashi;C. Ping;D. Min;A. Nakamura
通讯作者：
A. Nakamura
影响因子：
56.9
作者：
XIA, ZG;DICKENS, M;GREENBERG, ME
通讯作者：
GREENBERG, ME