A new constitutive model for hydration-dependent mechanical properties in biological soft tissues and hydrogels.
A new constitutive model for hydration-dependent mechanical properties in biological soft tissues and hydrogels.
复制标题
DOI：
10.1016/j.jbiomech.2014.06.012
复制
发表时间：
2014-09-22
影响因子：
2.4
通讯作者：
Gu, Weiyong
中科院分区：
文献类型：
--
作者：
Gao, Xin;Gu, Weiyong
关键词：
在体内无创测定生物软组织的力学性能是一项具有挑战性的工作。本文基于两相理论和输运模型，推导了一种新的水化软材料水化相关力学性能的本构模型：其中HA = λ + 2μ为骨料模量，λ f为流体体积分数（即，水合作用），A和n（>2）是与双相材料的输运性质相关的两个参数。验证了文献中水化依赖的剪切模量的线性模型的水凝胶。研究了组织水化对力学性能（骨料模量和泊松比）的影响。结果表明，在高含水量的软质材料中，泊松比的大小对组织水化非常敏感。该模型对水凝胶的聚集体模量和剪切模量的预测结果与实验结果吻合较好。这项研究是非常重要的开发新技术的非侵入性评估生物软组织的机械性能，使用定量MRI方法，以及设计具有适当的机械性能的组织工程应用支架。
It is challenging to noninvasively determine the mechanical properties of biological soft tissues in vivo. In this study, based on the biphasic theory and the transport models, a new constitutive model for hydration-dependent mechanical properties in hydrated soft materials was derived: , where HA = λ + 2μ is the aggregate modulus, ϕf is the volume fraction of fluid (i.e., hydration), A and n (>2) are two parameters related to the transport properties of the biphasic materials. A linear model for hydration-dependent shear modulus in the literature was verified for hydrogels. The effects of tissue hydration on mechanical properties (aggregate modulus and Poisson’s ratio) were investigated. It was found that the value of Poisson’s ratio was very sensitive to the tissue hydration in soft materials with high water content. The predictions of the aggregate modulus and shear modulus for hydrogels by the model compared well with those from experimental results. This study is important for developing new techniques for noninvasively assessing the mechanical properties of biological soft tissues using quantitative MRI methods as well as for designing scaffolds with proper mechanical properties for tissue engineering applications.
登录
查看更多内容
影响因子：
3.8
作者：
Gu, WY;Yao, H;Flagler, D
通讯作者：
Flagler, D
影响因子：
1.3
作者：
Kerttula, L;Kurunlahti, M;Tervonen, O
通讯作者：
Tervonen, O
影响因子：
3.5
作者：
Ateshian, Gerard A.
通讯作者：
Ateshian, Gerard A.
影响因子：
3.4
作者：
Hatami-Marbini, Hamed;Etebu, Ebitimi
通讯作者：
Etebu, Ebitimi
影响因子：
2.8
作者：
ATHANASIOU, KA;ROSENWASSER, MP;MOW, VC
通讯作者：
MOW, VC