Associations between ambient fine particulate levels and disease activity in patients with systemic lupus erythematosus (SLE).
Associations between ambient fine particulate levels and disease activity in patients with systemic lupus erythematosus (SLE).
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DOI：
10.1289/ehp.1002123
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发表时间：
2011-01
影响因子：
10.4
通讯作者：
Smargiassi A
中科院分区：
文献类型：
--
作者：
Bernatsky S;Fournier M;Pineau CA;Clarke AE;Vinet E;Smargiassi A
系统性红斑狼疮（SLE）是一种病因不明的慢性疾病，其特点是免疫系统过度活跃，产生的抗体可靶向许多器官系统的正常组织，包括肾脏。它可以发生在任何年龄，主要发生在女性身上。我们的目的是评估颗粒物（PM）空气污染对SLE临床的潜在影响。我们研究了居住在蒙特利尔岛的SLE患者的临床队列，随后每年进行结构化的临床评估。我们评估了固定站点监测站测量的环境细颗粒物（空气动力学直径中位数≤2.5 μm (PM2.5)）水平与SLE疾病活动性（SLE疾病活动性指数2000版（SLEDAI-2K））之间的关系，SLE疾病活动性包括抗双链DNA（抗dsdna）血清特异性自身抗体和尿中的肾小管细胞模态，这反映了严重的肾脏炎症。我们使用混合效应回归模型，根据日常环境温度和臭氧水平进行调整。我们评估了237名患者（223名女性），从2000年到2007年共就诊1083次（首次就诊时的平均年龄为41.2岁）。PM2.5水平与抗dsdna和细胞铸型有关。抗dsdna抗体的粗比值比和校正比值比（反映临床评估前48小时内PM2.5平均增加10 μg/m3）分别为1.26[95%置信区间（CI）， 0.96-1.65]和1.34 (95% CI, 1.02-1.77)，细胞铸型的粗比值比和校正比值比分别为1.43 （95% CI, 1.05-1.95）和1.28（0.92-1.80）。SLEDAI-2K总分与PM2.5水平无关。我们提供的新数据表明，空气污染的短期变化可能影响人类自身免疫性风湿病的疾病活动。我们的研究结果增加了人们的担忧，即污染可能是炎症和自身免疫的重要触发因素。
Systemic lupus erythematosus (SLE) is a chronic disease of unclear etiology, characterized by an overactive immune system and the production of antibodies that may target normal tissues of many organ systems, including the kidneys. It can arise at any age and occurs mainly in women. Our aim was to evaluate the potential influence of particulate matter (PM) air pollution on clinical aspects of SLE. We studied a clinic cohort of SLE patients living on the island of Montreal, followed annually with a structured clinical assessment. We assessed the association between ambient levels of fine PM [median aerodynamic diameter ≤ 2.5 μm (PM2.5)] measured at fixed-site monitoring stations and SLE disease activity measured with the SLE Disease Activity Index, version 2000 (SLEDAI-2K), which includes anti–double-stranded DNA (anti-dsDNA) serum-specific autoantibodies and renal tubule cellular casts in urine, which reflects serious renal inflammation. We used mixed effects regression models that we adjusted for daily ambient temperatures and ozone levels. We assessed 237 patients (223 women) who together had 1,083 clinic visits from 2000 through 2007 (mean age at time of first visit, 41.2 years). PM2.5 levels were associated with anti-dsDNA and cellular casts. The crude and adjusted odds ratios (reflecting a 10-μg/m3 increase in PM2.5 averaged over the 48 hr prior to clinical assessment) were 1.26 [95% confidence interval (CI), 0.96–1.65] and 1.34 (95% CI, 1.02–1.77) for anti-dsDNA antibodies and 1.43 (95% CI, 1.05–1.95) and 1.28 (0.92–1.80) for cellular casts. The total SLEDAI-2K scores were not associated with PM2.5 levels. We provide novel data that suggest that short-term variations in air pollution may influence disease activity in established autoimmune rheumatic disease in humans. Our results add weight to concerns that pollution may be an important trigger of inflammation and autoimmunity.
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DOI：
10.1165/ajrcmb.23.2.4035
发表时间：
2000-08-01
影响因子：
6.4
作者：
Shukla, A;Timblin, C;Mossman, BT
通讯作者：
Mossman, BT
影响因子：
10.4
作者：
Hart JE;Laden F;Puett RC;Costenbader KH;Karlson EW
通讯作者：
Karlson EW
影响因子：
2.6
作者：
Parks, C. G.;Cooper, G. S.
通讯作者：
Cooper, G. S.
影响因子：
2.1
作者：
Calderon-Garciduenas, L.;Villarreal-Calderon, R.;Reed, W.
通讯作者：
Reed, W.
影响因子：
--
作者：
Tseng, Chung-E;Buyon, Jill P.;Abramson, Steven B.
通讯作者：
Abramson, Steven B.