Are females who inject drugs at higher risk for HIV infection than males who inject drugs: an international systematic review of high seroprevalence areas.
Are females who inject drugs at higher risk for HIV infection than males who inject drugs: an international systematic review of high seroprevalence areas.
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DOI：
10.1016/j.drugalcdep.2011.12.020
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发表时间：
2012-07-01
影响因子：
4.2
通讯作者：
Hagan, Holly
中科院分区：
文献类型：
--
作者：
Des Jarlais, Don C.;Feelemyer, Jonathan P.;Modi, Shilpa N.;Arasteh, Kamyar;Hagan, Holly
关键词：
注射毒品的女性可能比注射毒品的男性更容易感染艾滋病毒，原因是多方面的。在这种情况下，需要为女性制定特别的艾滋病毒预防计划。对14个国家的研究进行国际系统审查和荟萃分析。从联合国艾滋病毒和注射毒品使用问题参考小组中确定了注射吸毒者中艾滋病毒流行(PWID)血清阳性率高(20%)的国家。系统的文献综述收集了这些国家按性别分列的艾滋病毒流行率数据。非参数和参数检验以及荟萃分析技术检查了不同研究之间的异质性和优势比(OR)的差异。数据摘自14个国家的117项研究；总样本量N=128,745。女性对男性HIV感染率的平均加权OR为1.18[95%可信区间为1.10~1.26]，研究间具有高度的异质性(I2=70.7%)。样本中各研究的对数比呈正态分布。与在高血清阳性率环境下注射毒品的男性相比，女性的艾滋病毒流行率明显更高，但影响规模非常小。高度的异质性和高斯分布表明，艾滋病毒感染率在女性和男性之间的差异有多种原因，其中一个具体的差异由当地因素决定。更好地了解可能保护女性免受艾滋病毒感染的因素，可能会为女性和注射毒品的男性提供更有效的艾滋病毒预防的见解。
There are multiple reasons why females who inject drugs may be more likely to become infected with HIV than males who inject drugs. Where this is the case, special HIV prevention programs for females would be needed. International systematic review and meta-analysis of studies across 14 countries. Countries with high seroprevalence (>20%) HIV epidemics among persons who inject drugs (PWID) were identified from the Reference Group to the UN on HIV and Injecting Drug Use. Systematic literature reviews collected data on HIV prevalence by gender for these countries. Non-parametric and parametric tests along with meta-analytic techniques examined heterogeneity and differences in odds ratios (OR) across studies. Data were abstracted from 117 studies in 14 countries; total sample size N=128,745. The mean weighted OR for HIV prevalence among females to males was 1.18 [95% CI 1.10–1.26], with high heterogeneity among studies (I2 = 70.7%). There was a Gaussian distribution of the log ORs across studies in the sample. There was a significantly higher HIV prevalence among females compared to males who inject drugs in high seroprevalence settings, but the effect size is extremely modest. The high level of heterogeneity and the Gaussian distribution suggest multiple causes of differences in HIV prevalence between females and males, with a specific difference determined by local factors. Greater understanding of factors that may protect females from HIV infection may provide insights into more effective HIV prevention for both females and males who inject drugs.
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影响因子：
4.2
作者：
Des Jarlais, Don C.;Arasteh, Kamyar;Friedman, Samuel R.
通讯作者：
Friedman, Samuel R.
影响因子：
2.3
作者：
BANKS S E;BROWN L S JR;AJULUCHUKWU D
通讯作者：
AJULUCHUKWU D
影响因子：
3.8
作者：
CHIASSON, MA;STONEBURNER, RL;JAFFE, HW
通讯作者：
JAFFE, HW
影响因子：
120.7
作者：
DESJARLAIS, DC;FRIEDMAN, SR;MARMOR, M
通讯作者：
MARMOR, M
影响因子：
11.8
作者：
Boschini, A;Smacchia, C;Rezza, G
通讯作者：
Rezza, G