Animal models of hidden hearing loss: Does auditory-nerve-fiber loss cause real-world listening difficulties?
Animal models of hidden hearing loss: Does auditory-nerve-fiber loss cause real-world listening difficulties?
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DOI：
10.1016/j.mcn.2021.103692
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Henry KS
中科院分区：
文献类型：
--
作者：
Henry KS
听神经对耳蜗的传入神经支配在衰老过程中下降，并可能在声音过度暴露后下降，产生耳蜗突触病的常见病理。听觉神经纤维的丧失很难用临床听力图检测出来，并且被认为会导致“隐性听力损失”，包括对噪音中的言语感知受损。尽管听觉神经纤维丧失导致人类隐性听力丧失的证据存在争议，但行为动物模型有望严格验证这一假设，因为神经损伤可以被诱导并在组织学上得到证实。在这里，我们回顾了最近的动物行为学研究中关于听觉神经纤维丢失对一系列物种感知的影响。我们首先考虑从惊声反射中推断出的耳鸣和超聋的研究，然后回顾听力图的操作性条件反射研究，不同持续时间的音调的时间整合，噪声间隙的时间分辨率和噪声中音调的检测。量化听音图的研究表明，除非神经损伤超过80%，否则听神经纤维的损失不会影响安静音的敏感性，在这一点上可能会有很大的缺陷。知觉的其他方面的变化，通常是针对50-70%的中重度听觉神经纤维损失进行的研究，在不同的研究中表现出异质性，与毛细胞病变引起的损害相比，可能是很小的。未来的研究应该遵循最近的发现，即对短暂音调和噪音中无声间隙的行为敏感性可能特别容易受到听觉神经纤维损失的影响。此外，与中枢抑制和精细神经反应时间相关的听觉感知方面，如调制掩蔽释放和空间听觉，可能是进一步动物行为学研究的有益方向。
Afferent innervation of the cochlea by the auditory nerve declines during aging and potentially after sound overexposure, producing the common pathology known as cochlear synaptopathy. Auditory-nerve-fiber loss is difficult to detect with the clinical audiogram and has been proposed to cause ‘hidden hearing loss’ including impaired speech-in-noise perception. While evidence that auditory-nerve-fiber loss causes hidden hearing loss in humans is controversial, behavioral animal models hold promise to rigorously test this hypothesis because neural lesions can be induced and histologically validated. Here, we review recent animal behavioral studies on the impact of auditory-nerve-fiber loss on perception in a range of species. We first consider studies of tinnitus and hyperacusis inferred from acoustic startle reflexes, followed by a review of operant-conditioning studies of the audiogram, temporal integration for tones of varying duration, temporal resolution of gaps in noise, and tone-in-noise detection. Studies quantifying the audiogram show that tone-in-quiet sensitivity is unaffected by auditory-nerve-fiber loss unless neural lesions exceed 80%, at which point large deficits are possible. Changes in other aspects of perception, which were typically investigated for moderate-to-severe auditory-nerve-fiber loss of 50–70%, appear heterogeneous across studies and might be small compared to impairment caused by hair-cell pathologies. Future studies should pursue recent findings that behavioral sensitivity to brief tones and silent gaps in noise may be particularly vulnerable to auditory-nerve-fiber loss. Furthermore, aspects of auditory perception linked to central inhibition and fine neural response timing, such as modulation masking release and spatial hearing, may be productive directions for further animal behavioral research.
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影响因子：
3
作者：
Bharadwaj HM;Verhulst S;Shaheen L;Liberman MC;Shinn-Cunningham BG
通讯作者：
Shinn-Cunningham BG
影响因子：
16.2
作者：
Chambers AR;Resnik J;Yuan Y;Whitton JP;Edge AS;Liberman MC;Polley DB
通讯作者：
Polley DB
影响因子：
2.7
作者：
Grose JH;Buss E;Hall JW 3rd
通讯作者：
Hall JW 3rd
DOI：
10.1007/978-1-4614-1590-9_43
发表时间：
2013-01-01
期刊：
BASIC ASPECTS OF HEARING: PHYSIOLOGY AND PERCEPTION
影响因子：
--
作者：
Carney, Laurel H.;Ketterer, Angela D.;Idrobo, Fabio
通讯作者：
Idrobo, Fabio
影响因子：
56.9
作者：
CORWIN, JT;COTANCHE, DA
通讯作者：
COTANCHE, DA