Meat and bone meal and mineral feed additives may increase the risk of oral prion disease transmission.
Meat and bone meal and mineral feed additives may increase the risk of oral prion disease transmission.
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DOI：
10.1080/15287394.2011.529066
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Aiken JM
中科院分区：
文献类型：
--
作者：
Johnson CJ;McKenzie D;Pedersen JA;Aiken JM
摄入朊病毒污染的物质被假定为朊病毒疾病传播的主要途径。与未结合的朊病毒相比，朊病毒与土壤（微）颗粒的结合显著增强了经口疾病传播，并且假设存在于其他消费材料中的微米级颗粒可能会影响朊病毒疾病通过口腔途径的传播。许多物质中都含有不溶性小颗粒，包括土壤、人类食物、药品和动物饲料。众所周知，肉骨粉（MBM）是一种被认为是导致牛海绵状脑病（BSE）传播的饲料添加剂，含有小于20 μm的颗粒，并且致病性朊病毒蛋白与MBM结合。通过暴露于MBM或三种微米大小的矿物质饲料添加剂，确定了通过口服途径的疾病传播的增强作用。数据显示，当病原体与任何测试材料结合时，与未结合的朊病毒相比，疾病的发病率增加。我们的数据表明，在动物或潜在的人类消耗的饲料或其他朊病毒污染的物质中，添加MBM或微粒的存在可能会增加朊病毒疾病的风险。
Ingestion of prion-contaminated materials is postulated to be a primary route of prion disease transmission. Binding of prions to soil (micro)particles dramatically enhances peroral disease transmission relative to unbound prions, and it was hypothesized that micrometer–sized particles present in other consumed materials may affect prion disease transmission via the oral route of exposure. Small, insoluble particles are present in many substances, including soil, human foods, pharmaceuticals, and animal feeds. It is known that meat and bone meal (MBM), a feed additive believed responsible for the spread of bovine spongiform encephalopathy (BSE), contains particles smaller than 20 μm and that the pathogenic prion protein binds to MBM. The potentiation of disease transmission via the oral route by exposure to MBM or three micrometer-sized mineral feed additives was determined. Data showed that when the disease agent was bound to any of the tested materials, the penetrance of disease was increased compared to unbound prions. Our data suggest that in feed or other prion–contaminated substances consumed by animals or, potentially, humans, the addition of MBM or the presence of microparticles could heighten risks of prion disease acquisition.
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