Nucleoside transporters and immunosuppressive adenosine signaling in the tumor microenvironment: Potential therapeutic opportunities.
Nucleoside transporters and immunosuppressive adenosine signaling in the tumor microenvironment: Potential therapeutic opportunities.
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DOI：
10.1016/j.pharmthera.2022.108300
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发表时间：
2022-12
影响因子：
13.5
通讯作者：
Govindarajan, Rajgopal
中科院分区：
文献类型：
--
作者：
Kaur, Tejinder;Weadick, Brenna;Mace, Thomas A.;Desai, Kajal;Odom, Hannah;Govindarajan, Rajgopal
腺苷区室化通过调节腺苷定位并因此调节细胞外信号传导能力对免疫细胞功能具有深远影响，其抑制肿瘤微环境中的免疫细胞功能。核苷转运蛋白，负责亲水性腺苷的易位和细胞区室化，是肿瘤微环境中腺苷分布的一个未充分研究但至关重要的组成部分。在这篇综述文章中，我们将总结关于核苷转运蛋白在嘌呤组中的功能与目前设计的干预点（即，外核苷酸酶，腺苷受体）用于癌症免疫治疗，癌症中报道的核苷转运蛋白表达的改变，以及靶向核苷转运蛋白用于腺苷区室化和作用的所需调节的潜在途径。此外，我们提出，核苷转运蛋白是一个未开发的治疗机会，核苷转运过程的调制可以减弱免疫抑制腺苷在实体瘤中的致病性积累，特别是那些富含核苷转运蛋白的肿瘤。
Adenosine compartmentalization has a profound impact on immune cell function by regulating adenosine localization and, therefore, extracellular signaling capabilities, which suppresses immune cell function in the tumor microenvironment. Nucleoside transporters, responsible for the translocation and cellular compartmentalization of hydrophilic adenosine, represent an understudied yet crucial component of adenosine disposition in the tumor microenvironment. In this review article, we will summarize what is known regarding nucleoside transporter’s function within the purinome in relation to currently devised points of intervention (i.e., ectonucleotidases, adenosine receptors) for cancer immunotherapy, alterations in nucleoside transporter expression reported in cancer, and potential avenues for targeting of nucleoside transporters for the desired modulation of adenosine compartmentalization and action. Further, we put forward that nucleoside transporters are an unexplored therapeutic opportunity, and modulation of nucleoside transport processes could attenuate the pathogenic buildup of immunosuppressive adenosine in solid tumors, particularly those enriched with nucleoside transport proteins.
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影响因子：
4.8
作者：
Baldwin, SA;Yao, SYM;Young, JD
通讯作者：
Young, JD
腺苷和睡眠。
影响因子：
5.3
作者：
Bjorness TE;Greene RW
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Greene RW
DOI：
10.1084/jem.20151193
发表时间：
2016-10-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Afik R;Zigmond E;Vugman M;Klepfish M;Shimshoni E;Pasmanik-Chor M;Shenoy A;Bassat E;Halpern Z;Geiger T;Sagi I;Varol C
通讯作者：
Varol C
影响因子：
4.7
作者：
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Peng L
影响因子：
6.7
作者：
Bodin, P;Burnstock, G
通讯作者：
Burnstock, G