Dopamine D3 receptor regulates basal but not amphetamine-induced changes in pain sensitivity in mice
Dopamine D3 receptor regulates basal but not amphetamine-induced changes in pain sensitivity in mice
复制标题
多巴胺 D3 受体调节小鼠疼痛敏感性的基础变化，但不调节安非他明引起的变化
DOI：
10.1016/j.neulet.2010.04.049
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发表时间：
2010-06
影响因子：
2.5
通讯作者：
Chen, Teng
中科院分区：
文献类型：
--
作者：
Zhu, Jie;Chen, Yanjiong;Lai, Jianghua;Dang, Yonghui;Yan, Chunxia;Xu, Ming;Chen, Teng
疼痛是一种复杂的主观体验，不仅涉及到痛觉纤维对有害刺激的传导，还涉及到大脑对认知和情绪的处理。以往关于伤害感觉传递的研究表明，中脑边缘多巴胺（DA）系统的激活在强直性疼痛的抑制中起着重要作用。本研究的目的是研究DA D3受体在调节小鼠基础和安非他明诱导的疼痛敏感性变化中的作用。我们使用野生型和D3受体突变小鼠，并测定了由有害热（辐射热）和机械（von Frey毛发）刺激引起的异位性疼痛。我们发现，与野生型小鼠相比，D3受体突变小鼠在甩尾试验和von Frey毛发试验中均表现出痛觉减退。在甩尾试验和von Frey毛发试验中，安非他明诱导的D3受体突变型和野生型小鼠痛觉过敏。在甩尾试验和von Frey毛发试验中，野生型和D3受体突变型小鼠在给予安非他明后疼痛敏感性的相对变化无显著差异。这些结果表明D3受体调节伤害感觉的传递。此外，安非他明可以降低小鼠的疼痛阈值。
Pain is a complex and subjective experience that involves not only the transduction of noxious stimuli by nociceptive fibers, but also the cognitive and emotional processing by the brain. Previous studies on the transmission of nociception suggest that the activation of mesolimbic dopamine (DA) system plays an important role in mediating the suppression of tonic pain. The aim of the current study was to examine the role of DA D3 receptor in modulating basal and amphetamine-induced changes in pain sensitivity in mice. We used wild-type and D3 receptor mutant mice and determined allodynia induced by both noxious heat (radiant heat) and mechanical (von Frey hair) stimuli. We show that D3 receptor mutant mice exhibit hypoalgesia in both the tail-flick test and von Frey hair test compared to wild-type mice. Amphetamine-induced hyperalgesia in both D3 receptor mutant and wild-type mice in the tail-flick test and von Frey hair test. There was no significantly difference in the relative change in pain sensitivity between wild-type and D3 receptor mutant mice in both the tail-flick test and von Frey hair test following amphetamine administration. These results suggest that the D3 receptor regulates the transmission of nociception. Moreover, amphetamine can lower pain threshold in mice.
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影响因子：
2.9
作者：
K. Follett
通讯作者：
K. Follett
DOI：
10.1523/jneurosci.12-02-00483.1992
发表时间：
1992-02
期刊：
--
影响因子：
--
作者：
S. Johnson;R. North
通讯作者：
S. Johnson;R. North
DOI：
10.1007/bf00215299
发表时间：
2004
期刊：
Anatomy and Embryology
影响因子：
--
作者：
W. Smeets;L. Medina
通讯作者：
W. Smeets;L. Medina
影响因子：
3.3
作者：
MANNING, BH;MORGAN, MJ;FRANKLIN, KBJ
通讯作者：
FRANKLIN, KBJ
影响因子：
2.9
作者：
B. Sandrew;D. Edwards;C. Poletti;W. Foote
通讯作者：
B. Sandrew;D. Edwards;C. Poletti;W. Foote