Relaxation response induces temporal transcriptome changes in energy metabolism, insulin secretion and inflammatory pathways.
Relaxation response induces temporal transcriptome changes in energy metabolism, insulin secretion and inflammatory pathways.
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DOI：
10.1371/journal.pone.0062817
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Libermann TA
中科院分区：
文献类型：
--
作者：
Bhasin MK;Dusek JA;Chang BH;Joseph MG;Denninger JW;Fricchione GL;Benson H;Libermann TA
松弛反应（RR）是应力反应的对应物。数千年的传统活动包括冥想、瑜伽和重复祈祷。虽然RR激发是一种有效的治疗干预措施，可以抵消高血压、焦虑、失眠和衰老等疾病中应激的不良临床影响，但解释这些临床益处的潜在分子机制仍未确定。为了评估具有多年RR实践经验的健康从业者和新手在RR培训前后8周的一次RR实践期间快速的时间依赖性（时间）基因组变化，我们测量了在RR培训之前，之后立即，短期从业人员和长期从业人员在时间上的基因表达变化都显著，后者比新手更显著。抗风险治疗增强了与能量代谢、线粒体功能、胰岛素分泌和端粒维持相关的基因表达，减少了与炎症反应和压力相关途径相关的基因表达。对rr影响通路的交互网络分析发现，线粒体ATP合成酶和胰岛素（INS）是最高上调的关键分子（焦点枢纽），NF-κB通路基因是最高下调的焦点枢纽。我们的研究结果首次表明，特别是在长期练习后，RR激发可能通过提高线粒体能量的产生和利用，从而通过上调atp酶和胰岛素功能促进线粒体的恢复能力，从而引起其下游健康益处。rr诱导的NF-κ b相关上下游靶标下调也可能促进线粒体的恢复能力，从而减轻应激。
The relaxation response (RR) is the counterpart of the stress response. Millennia-old practices evoking the RR include meditation, yoga and repetitive prayer. Although RR elicitation is an effective therapeutic intervention that counteracts the adverse clinical effects of stress in disorders including hypertension, anxiety, insomnia and aging, the underlying molecular mechanisms that explain these clinical benefits remain undetermined. To assess rapid time-dependent (temporal) genomic changes during one session of RR practice among healthy practitioners with years of RR practice and also in novices before and after 8 weeks of RR training, we measured the transcriptome in peripheral blood prior to, immediately after, and 15 minutes after listening to an RR-eliciting or a health education CD. Both short-term and long-term practitioners evoked significant temporal gene expression changes with greater significance in the latter as compared to novices. RR practice enhanced expression of genes associated with energy metabolism, mitochondrial function, insulin secretion and telomere maintenance, and reduced expression of genes linked to inflammatory response and stress-related pathways. Interactive network analyses of RR-affected pathways identified mitochondrial ATP synthase and insulin (INS) as top upregulated critical molecules (focus hubs) and NF-κB pathway genes as top downregulated focus hubs. Our results for the first time indicate that RR elicitation, particularly after long-term practice, may evoke its downstream health benefits by improving mitochondrial energy production and utilization and thus promoting mitochondrial resiliency through upregulation of ATPase and insulin function. Mitochondrial resiliency might also be promoted by RR-induced downregulation of NF-κB-associated upstream and downstream targets that mitigates stress.
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影响因子：
10.6
作者：
Antoni, Michael H.;Lutgendorf, Susan K.;Blomberg, Bonnie;Carver, Charles S.;Lechner, Suzanne;Diaz, Alain;Stagl, Jamie;Arevalo, Jesusa M. G.;Cole, Steven W.
通讯作者：
Cole, Steven W.
影响因子：
5.2
作者：
Epel E;Daubenmier J;Moskowitz JT;Folkman S;Blackburn E
通讯作者：
Blackburn E
DOI：
10.1002/art.10416
发表时间：
2002-06-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Astin, JA;Beckner, W;Berman, B
通讯作者：
Berman, B
影响因子：
--
作者：
Fisher, RA
通讯作者：
Fisher, RA
DOI：
10.1164/rccm.200406-710st
发表时间：
2005-04-15
影响因子：
24.7
作者：
American Thoracic Society;European Respiratory Society
通讯作者：
European Respiratory Society