Cyclic loading effects on craniofacial strain and sutural growth in pigs.
Cyclic loading effects on craniofacial strain and sutural growth in pigs.
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DOI：
10.1016/j.ajodo.2017.11.036
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发表时间：
2018-08
期刊：
影响因子：
--
通讯作者：
Herring S
中科院分区：
文献类型：
--
作者：
Soh SH;Rafferty K;Herring S
目前的颅面生长矫正装置利用静力，但一些人认为循环力更有效。后者还没有在大型动物模型中进行评估，目前还不知道这种力量是如何传递到头骨的远端部分的。本研究的目的是：1.开发一种便携式加载系统，能够向猪鼻额缝提供可靠的循环载荷；2.探索应变向远端缝合的传递；3.在小型先导性研究中表征缝合生长的影响。在验证该装置后，对屠宰场猪头(n=6)的神经纤维处施加周期性(2.5 Hz)拉伸载荷，在多条缝合线上安装应变片。3月龄生猪(Sus scrofa，n=4，1只假猪)每天30min，连续5d，施加相同的负荷。在实验第1天和第3天进行矿化荧光标记，第5天记录缝线张力，组织形态计量学定量测量缝线宽度和矿物质沉积率(MAR)。一种可穿戴的加载系统被开发出来，在目标NFS处产生平均+900NF值的με。在对侧的骨缝和中线缝合处有很大的应变，但骨应变很低。体内和体外的应变模式是相似的，后者通常具有更高的强度。初步证据表明，在加载的缝合线中，更宽的缝合线具有更高的MARS。每天的循环负荷会导致整个头骨的缝合线拉伤。该方案可能会促进缝合生长，并可能在治疗上有用。
Current craniofacial growth modification devices utilize static forces but cyclic forces are believed by some to be more effective. The latter has not been evaluated in large animal models, and it is not known how such forces are transmitted to distant parts of the skull. This study aims to: 1. Develop a portable loading system capable of delivering reliable cyclic loads to the porcine nasofrontal suture (NFS), 2. Explore strain transmission to distant sutures and 3. Characterize the sutural growth effects in a small pilot study. After validating the device, cyclic (2.5Hz) tensile loads were applied unilaterally to the NFS of abattoir pig heads (n=6), with strain gages on multiple sutures. Similar loading was applied to 3-month old live pigs (Sus scrofa, n=4 and 1 sham) 30 minutes/day for 5 days. These animals received fluorescent markers of mineralization on loading days 1 and 3. Suture strains were recorded on day 5. Histomorphometric analysis quantified suture width and mineral apposition rate (MAR). A wearable loading system was developed to produce an average of +900 με at the targeted NFS. Substantial strains were seen at the contralateral NFS and midline sutures, but bone strains were low. Strain patterns were similar ex vivo and in vivo, with the latter generally having higher magnitudes. Preliminary evidence demonstrates wider sutures with higher MARs in the loaded sutures. Daily spurts of cyclic load caused sutural strain throughout the skull. The regime likely enhances suture growth and may be therapeutically useful.
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影响因子：
3.1
作者：
Ibrahim, A. Y.;Gudhimella, S.;Huja, S. S.
通讯作者：
Huja, S. S.
DOI：
10.1016/j.ajodo.2013.04.022
发表时间：
2013-11-01
影响因子：
3
作者：
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通讯作者：
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影响因子：
4.1
作者：
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通讯作者：
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DOI：
10.1016/0002-9416(79)90278-1
发表时间：
1979-01-01
影响因子：
3
作者：
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通讯作者：
SHAPIRO, PA
影响因子：
6.2
作者：
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通讯作者：
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