Experimental study of bone formation from autogenous periosteal graft following insulin-like growth factor I administration.
Experimental study of bone formation from autogenous periosteal graft following insulin-like growth factor I administration.
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胰岛素样生长因子 I 给药后自体骨膜移植骨形成的实验研究。
DOI：
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发表时间：
1999
期刊：
影响因子：
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通讯作者：
T. Sugahara
中科院分区：
文献类型：
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作者：
T. Ueno;N. Mizukawa;T. Sugahara
本研究评价了胰岛素样生长因子I（IGF-I）给药对骨膜移植后骨形成的影响。将24只日本白色家兔随机分配至一个IGF-I给药组（1 mg，持续14天）和第二个对照组。取胫骨移植骨膜置于下颌下肌下。分别于术后14、21、28天取出移植骨膜进行检查。在整个实验的所有阶段中，在对照组和实验组中均通过组织学和放射学证实了活跃的骨形成。此外，微CT扫描用于观察新形成的骨中的三维微观结构，并测量骨小梁厚度作为骨发育的标志物。结果，与对照组相比，IGF-I组中观察到骨形成显著增加。移植后14天和21天，IGF-I组的松质骨厚度显著大于对照组（P < 0.01）。在移植后28天，没有显着差异，这表明IGF-I的管理可能发挥重要作用，诱导骨形成从移植骨膜在早期阶段。
The present study evaluates the effect of insulin-like growth factor I (IGF-I) administration on bone formation following grafted periosteum. Twenty-four Japanese white rabbits were randomly assigned into one IGF-I administered group (1 mg for 14 days) and a second control group. Grafted periosteum taken from the tibia was placed under the submandibular muscles. At 14, 21, and 28 days following the operation, the grafted periosteum was extirpated and examined. Throughout all stages of the experiment, active bone formation was confirmed histologically and radiographically in both control and experimental groups. In addition, a micro-CT scan was used to observe three-dimensional micro structures in newly formed bone and to measure the trabecular bone thickness as a marker of bone development. As a result, a significant increase in bone formation in the IGF-I group was observed when compared with the findings in the control group. Trabecular bone thickness in the IGF-I group was significantly greater when compared with the control group at 14 days and 21 days following grafting (P < 0.01). At 28 days following grafting, there were no significant differences, suggesting that administration of IGF-I may play an important role in inducing bone formation from grafted periosteum in the early stages.
甲状旁腺激素阻断胰岛素样生长因子-I 对培养的 21 天胎鼠颅盖胶原蛋白合成的刺激作用。
影响因子：
4.1
作者：
Kream,BE;Petersen,DN;Raisz,LG
通讯作者：
Raisz,LG
胰岛素样生长因子-I (IGF-I) 对大鼠骨形成和吸收的体内作用。
影响因子：
4.1
作者：
Spencer,EM;Liu,CC;Si,EC;Howard,GA
通讯作者：
Howard,GA