Mouse Brachyury the Second (T2) is a gene next to classical T and a candidate gene for tct.

Mouse Brachyury the Second (T2) is a gene next to classical T and a candidate gene for tct.
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小鼠 Brachyury the Second (T2) 是仅次于经典 T 的基因,也是 tct 的候选基因。

DOI:
10.1093/genetics/150.3.1125
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发表时间:
1998
期刊:
影响因子:
3.3
通讯作者:
Artzt,K
Artzt,K
中科院分区:
生物学2区
文献类型:
--
作者:
Rennebeck,G;Lader,E;Fujimoto,A;Lei,EP;Artzt,K

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小鼠Brachyury The Second (T2)基因与经典Brachyury (T)基因相距15kb。T2突变破坏脊索发育,表明存在第二个参与轴发育的T/ T复合基因。T2编码一种新蛋白,该蛋白可通过插入T2Bobmice而被破坏。对多个t单倍型的T2序列分析表明,它们都具有相同的变化终止密码子,因此,T2是t复合体尾部相互作用因子的候选基因。T1、T2和未连接的t-int是不同的、不相关的基因座,这些基因的突变在遗传上并不互补。要么它们的产物在胚胎轴的形成过程中在相同的途径中相互作用,要么T/ T区域本身真的很复杂。
The mouse Brachyury the Second (T2) gene is 15 kb away from classical Brachyury (T). A mutation in T2 disrupts notochord development, pointing to the existence of a second T/t complex gene involved in axis development. T2 encodes a novel protein that is disrupted by an insertion in T2Bobmice. Sequence analysis of T2 from several t haplotypes shows that they all share the same changed stop codon, and, thus, T2 is a candidate gene for the t complex tail interaction factor. T1, T2, and the unlinked t-int are distinct and unrelated loci, and mutations in these genes do not complement one another genetically. Either their products interact in the same pathway during the genesis of the embryonic axis, or the T/t region itself is truly complex.
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期刊: SCIENCE
影响因子: 56.9
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