Neurotrophic factors in the physiology of motor neurons and their role in the pathobiology and therapeutic approach to amyotrophic lateral sclerosis.
Neurotrophic factors in the physiology of motor neurons and their role in the pathobiology and therapeutic approach to amyotrophic lateral sclerosis.
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DOI：
10.3389/fnmol.2023.1238453
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发表时间：
2023
影响因子：
4.8
通讯作者：
Pierchala, Brian
中科院分区：
文献类型：
--
作者：
Stansberry, Wesley;Pierchala, Brian
神经营养因子的发现及其强大的生存和营养作用使人们对其在神经退行性疾病中拯救垂死神经元的治疗潜力充满热情。进一步发现脑源性神经营养因子（BDNF）、睫状体神经营养因子（CNTF）和胶质细胞系源性神经营养因子（GDNF）对运动神经元具有有效的促生存活性，从而提出将其用于肌萎缩性侧索硬化症（ALS）等运动神经元疾病。在这篇综述中，我们综合了有关NGF、BDNF、CNTF和GDNF在脊髓运动神经元发育和生理中的作用的文献，以及评估它们治疗ALS潜力的临床前研究。这些分子的临床试验结果也将被描述，在几十年的后见之明的帮助下，我们将讨论可以合理地得出什么结论，以及这些信息如何为肌萎缩侧索硬化症神经营养因子的未来临床发展提供信息。
The discovery of the neurotrophins and their potent survival and trophic effects led to great enthusiasm about their therapeutic potential to rescue dying neurons in neurodegenerative diseases. The further discovery that brain-derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF) and glial cell line-derived neurotrophic factor (GDNF) had potent survival-promoting activity on motor neurons led to the proposal for their use in motor neuron diseases such as amyotrophic lateral sclerosis (ALS). In this review we synthesize the literature pertaining to the role of NGF, BDNF, CNTF and GDNF on the development and physiology of spinal motor neurons, as well as the preclinical studies that evaluated their potential for the treatment of ALS. Results from the clinical trials of these molecules will also be described and, with the aid of decades of hindsight, we will discuss what can reasonably be concluded and how this information can inform future clinical development of neurotrophic factors for ALS.
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影响因子：
3.6
作者：
Donnelly CR;Pierchala BA
通讯作者：
Pierchala BA
影响因子：
64.5
作者：
Bonanomi D;Chivatakarn O;Bai G;Abdesselem H;Lettieri K;Marquardt T;Pierchala BA;Pfaff SL
通讯作者：
Pfaff SL
影响因子：
3.4
作者：
Li JT;Dong SQ;Qian T;Yang WB;Chen XJ
通讯作者：
Chen XJ
影响因子：
3.4
作者：
通讯作者：
--
影响因子：
64.5
作者：
DECHIARA, TM;VEJSADA, R;YANCOPOULOS, GD
通讯作者：
YANCOPOULOS, GD