Fecal calprotectin levels are higher in rural than in urban Chinese infants and negatively associated with growth.
Fecal calprotectin levels are higher in rural than in urban Chinese infants and negatively associated with growth.
复制标题
中国农村婴儿的粪便钙卫蛋白水平高于城市婴儿，且与生长呈负相关
DOI：
10.1186/1471-2431-12-129
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发表时间：
2012-08-23
期刊：
影响因子：
2.4
通讯作者：
Hambidge KM
中科院分区：
文献类型：
--
作者：
Liu JR;Sheng XY;Hu YQ;Yu XG;Westcott JE;Miller LV;Krebs NF;Hambidge KM
背景粪便钙卫蛋白（FC）是公认的肠道炎症的简单生物标志物。为了研究线性增长和肠道炎症之间可能存在的关系，我们比较了粪便钙卫蛋白水平在6个月大的婴儿从贫困的农村与富裕的城市家庭。MethodsThe项目是一个横截面比较FC从农村和城市人口在中国。比较了不同年龄组的身长-年龄Z值（LAZ）与FC浓度的关系。单个粪便样本进行测定FC使用EK-CAL ELISA kitch.ResultsThe年龄的受试者为两个位置为6.1 ± 0.2个月，所有人都明显健康。农村和城市婴儿的LAZ平均值±标准差分别为-0.6 ± 0.9和0.4 ± 0.9。FC呈非正态分布。农村和城市婴儿的FC中位数分别为420.9和140.1 μg/g，差异有显著性（P< 0.0001）。对于农村组，线性回归分析表明，FC增加100 μg/g与LAZ.ConclusionFC水平下降0.06在农村婴儿和高浓度占约三分之一的低LAZ分数的这些婴儿显着升高。
BackgroundFecal calprotectin (FC) is an established simple biomarker of gut inflammation. To examine a possible relationship between linear growth and gut inflammation, we compared fecal calprotectin levels in 6 month old infants from poor rural vs affluent urban families.MethodsThe project was a cross-sectional comparison of FC from rural and urban populations in China. The relationship between length-for-age Z-score (LAZ) and FC concentrations were also compared. Single fecal samples were assayed for FC using EK-CAL ELISA kits.ResultsThe age of subjects for both locations was 6.1 ± 0.2 mo; all were apparently healthy. The mean ± SD of the LAZ for the rural and urban infants were −0.6 ± 0.9 and 0.4 ± 0.9, respectively. FC had a non-normal distribution. The median FC of 420.9 and 140.1 μg/g for rural and urban infants, respectively, were significantly different (P< 0.0001). For the rural group, linear regression analysis showed that an increase in FC of 100 μg/g was associated with a decrease of 0.06 in LAZ.ConclusionFC levels were significantly elevated in the rural infants and high concentrations accounted for approximately one-third of the low LAZ scores of these infants.
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DOI：
10.1097/00005176-200408000-00005
发表时间：
2004-08-01
影响因子：
2.9
作者：
Campbell, DI;McPhail, G;Jeffries, DJ
通讯作者：
Jeffries, DJ
影响因子：
28.2
作者：
Hanevik, Kurt;Flausken, Trygve;Langeland, Nina
通讯作者：
Langeland, Nina
影响因子：
3.2
作者：
Roseth, AG;Aadland, E;Raknerud, N
通讯作者：
Raknerud, N
影响因子：
4.5
作者：
Canani, R. Berni;Terrin, G.;Troncone, R.
通讯作者：
Troncone, R.
影响因子：
4.9
作者：
van Rheenen, Patrick F.
通讯作者：
van Rheenen, Patrick F.