Mapping the Mechanical and Immunological Profiles of Polymeric Microneedles to Enable Vaccine and Immunotherapy Applications.
Mapping the Mechanical and Immunological Profiles of Polymeric Microneedles to Enable Vaccine and Immunotherapy Applications.
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DOI：
10.3389/fimmu.2022.843355
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发表时间：
2022
影响因子：
7.3
通讯作者：
Jewell CM
中科院分区：
文献类型：
--
作者：
Shah SA;Oakes RS;Kapnick SM;Jewell CM
生物材料在疫苗和免疫治疗方面具有巨大的前景。一种新兴的生物材料技术是微针（MN）递送。MN是微米大小的针阵列，其是无痛的并且有效地将货物递送到皮肤的专门免疫生态位。MN通常不需要冷藏，并且消除了医疗尖锐物。几乎所有的材料都表现出内在的特性，可以使免疫反应偏向于促免疫或抑制作用。因此，由于MN由可降解聚合物制成以实现货物装载和释放，因此了解这些基质的免疫学特性对于实现新的MN疫苗和免疫疗法至关重要。此外，了解机械性能是重要的，因为MN必须穿透皮肤并符合各种皮肤或组织几何形状。在这里，我们从重要的聚合物类别制造MN-包括细胞外基质生物聚合物，天然衍生的聚合物和合成聚合物-具有高分子量和低分子量（MW）。然后，我们的特点是这些设计的机械性能和内在的免疫学特性。聚合物MNs库表现出不同的机械性能，同时仅引起先天信号传导和抗原特异性T细胞增殖的适度变化。这些数据有助于根据特定疫苗或免疫治疗应用所需的机械和免疫学要求选择MN底物。
Biomaterials hold great promise for vaccines and immunotherapy. One emerging biomaterials technology is microneedle (MNs) delivery. MNs are arrays of micrometer-sized needles that are painless and efficiently deliver cargo to the specialized immunological niche of the skin. MNs typically do not require cold storage and eliminate medical sharps. Nearly all materials exhibit intrinsic properties that can bias immune responses toward either pro-immune or inhibitory effects. Thus, because MNs are fabricated from degradable polymers to enable cargo loading and release, understanding the immunological profiles of these matrices is essential to enable new MN vaccines and immunotherapies. Additionally, understanding the mechanical properties is important because MNs must penetrate the skin and conform to a variety of skin or tissue geometries. Here we fabricated MNs from important polymer classes – including extracellular matrix biopolymers, naturally-derived polymers, and synthetic polymers – with both high- and low-molecular-weights (MW). We then characterized the mechanical properties and intrinsic immunological properties of these designs. The library of polymer MNs exhibited diverse mechanical properties, while causing only modest changes in innate signaling and antigen-specific T cell proliferation. These data help inform the selection of MN substrates based on the mechanical and immunological requirements needed for a specific vaccine or immunotherapy application.
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影响因子：
10.8
作者：
Hasan W;Chu K;Gullapalli A;Dunn SS;Enlow EM;Luft JC;Tian S;Napier ME;Pohlhaus PD;Rolland JP;DeSimone JM
通讯作者：
DeSimone JM
影响因子：
9.7
作者：
Andorko JI;Hess KL;Pineault KG;Jewell CM
通讯作者：
Jewell CM
影响因子：
4.6
作者：
Fries CN;Chen JL;Dennis ML;Votaw NL;Eudailey J;Watts BE;Hainline KM;Cain DW;Barfield R;Chan C;Moody MA;Haynes BF;Saunders KO;Permar SR;Fouda GG;Collier JH
通讯作者：
Collier JH
影响因子：
4.6
作者：
Bok, Moonjeong;Zhao, Zhi-Jun;Lim, Eunju
通讯作者：
Lim, Eunju
影响因子：
10
作者：
He, Rongyan;Niu, Yan;Li, Fei
通讯作者：
Li, Fei