Complex Organization in Multicellularity as a Necessity in Evolution

Complex Organization in Multicellularity as a Necessity in Evolution
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多细胞中的复杂组织是进化的必要条件

DOI:
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发表时间:
2000
期刊:
影响因子:
2.6
通讯作者:
K. Kaneko
K. Kaneko
中科院分区:
计算机科学4区
文献类型:
--
作者:
C. Furusawa;K. Kaneko

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通过引入一个多细胞系统的动力学系统模型,它表明,一个生物体的各种分化的细胞类型和复杂的模式出现通过细胞间的相互作用,即使没有假设任何精心的控制机制。这样的有机体被发现保持一个更大的增长速度作为一个整体,通过实现资源的合作使用,比简单的同质细胞,表现自私。这表明,具有复杂组织的多细胞生物的出现是进化的必然。根据我们的理论模型,最初出现多能干细胞,它们经历随机分化为其他细胞类型。随着发育和分化,细胞内动力学的化学多样性和复杂性都降低了,这是我们系统的一般结果。还证实了开发过程的耐用性。
By introducing a dynamical system model of a multicellular system, it is shown that an organism with a variety of differentiated cell types and a complex pattern emerges through cell-cell interactions even without postulating any elaborate control mechanism. Such an organism is found to maintain a larger growth speed as an ensemble, by achieving a cooperative use of resources, than do simple homogeneous cells, which behave selfishly. This suggests that the emergence of multicellular organisms with complex organization is a necessity in evolution. According to our theoretical model, there initially appear multipotent stem cells, which undergo stochastic differentiation to other cell types. With development and differentiation, both the chemical diversity and the complexity of intra-cellular dynamics are decreased, as a general consequence of our system. Robustness of the developmental process is also confirmed.
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