Increased Absolute Glutamate Concentrations and Glutamate-to-Creatine Ratios in Patients With Methamphetamine Use Disorders.
Increased Absolute Glutamate Concentrations and Glutamate-to-Creatine Ratios in Patients With Methamphetamine Use Disorders.
复制标题
甲基苯丙胺使用障碍患者的绝对谷氨酸浓度和谷氨酸与肌酸比率增加
DOI：
10.3389/fpsyt.2018.00368
复制
发表时间：
2018
影响因子：
4.7
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Yang W;Yang R;Luo J;He L;Liu J;Zhang J
简介：以往的研究表明，谷氨酸和相关代谢物的浓度变化可能介导的成瘾性甲基苯丙胺（MA）使用障碍患者的进展。在本研究中，我们利用磁共振波谱（MRS）调查绝对谷氨酸浓度和代谢物的比例与MA成瘾患者。我们进一步分析了谷氨酸浓度与各种临床指标之间的相关性。研究方法：本研究包括31例临床诊断为MA依赖的未用药患者（平均年龄：30.5 ± 8.0岁）和32例年龄匹配的健康对照（平均年龄：32.9 ± 8.2岁）。使用Barratt冲动量表（BIS-11）对患者进行评估。我们还收集了有关药物使用持续时间和剂量的一般信息。使用点分辨光谱法定量代谢物（谷氨酸、胆碱、N-乙酰天冬氨酸、谷氨酰胺和肌酸）的绝对浓度，以及代谢物与总肌酸的比值（使用LCModel软件）。然后，我们比较了两组之间谷氨酸水平和心理测量分数的差异。结果：MA组脑干谷氨酸/肌酸比值显著高于对照组（t = 2.764，p = 0.008）。MA组脑干中的谷氨酸浓度也显著高于对照组（t = 2.390，p = 0.020）。然而，两组之间未观察到其他代谢物的浓度或比率的显著差异（均p > 0.05）。谷氨酸浓度与药物使用持续时间（r = 0.401，p = 0.035）和常规成瘾总剂量（成瘾持续时间×常规成瘾剂量; r = 0.207，p = 0.040）呈正相关，但与BIS-11评分无关。结论：我们的研究结果表明，脑干谷氨酸水平显着升高的MA使用障碍患者，这些水平显着相关的药物使用的时间和剂量，这些研究结果表明，谷氨酸浓度可以作为一个客观的生物学指标，用于评估/监测疾病状态和治疗效果的MA依赖患者。
Introduction: Previous studies have indicated that changes in the concentration of glutamate and related metabolites may mediate the progression of addiction in patients with methamphetamine (MA) use disorders. In the present study, we utilized magnetic resonance spectroscopy (MRS) to investigate absolute glutamate concentrations and metabolite ratios in patients with MA addiction. We further analyzed the association between glutamate concentration and various clinical indicators. Methods: The present study included 31 unmedicated patients with clinically diagnosed MA dependence (mean age: 30.5 ± 8.0 years) and 32 age-matched healthy controls (mean age: 32.9 ± 8.2 years). Patients were evaluated using the Barratt Impulsiveness Scale (BIS-11). We also collected general information regarding the duration and dosage of drug use. Point-resolved spectroscopy was used to quantify the absolute concentrations of metabolites (glutamate, choline, N-acetylaspartate, glutamine, and creatine), as well as the ratio of metabolites to total creatine, using LCModel software. We then compared differences in glutamate levels and psychometric scores between the two groups. Results: Glutamate-to-creatine ratios in the brainstem were significantly higher in the MA group than in the control group (t = 2.764, p = 0.008). Glutamate concentrations in the brainstem were also significantly higher in the MA group than in the control group (t = 2.390, p = 0.020). However, no significant differences in the concentrations or ratios of other metabolites were observed between the two groups (all p > 0.05). Glutamate concentration was positively correlated with the duration of drug use (r = 0.401, p = 0.035) and the total dose of regular addiction (duration of addiction × regular addiction dose; r = 0.207, p = .040), but not with BIS-11 scores. Conclusions: Our findings indicated that glutamate levels in the brainstem are significantly elevated in patients with MA use disorders, and that these levels are significantly associated with the duration and dose of drug use.Such findings suggest that glutamate concentration can be used as an objective biological marker for evaluating/monitoring disease status and treatment efficacy in patients with MA dependence.
登录
查看更多内容
影响因子：
8.2
作者：
George, Olivier;Koob, George F.
通讯作者：
Koob, George F.
与奖励相关行为中的多巴胺信号传导。
影响因子：
3.5
作者：
Baik JH
通讯作者：
Baik JH
影响因子：
4.7
作者：
Lammel S;Lim BK;Malenka RC
通讯作者：
Malenka RC
DOI：
10.1002/mds.26556
发表时间：
2016-05
期刊：
Movement disorders : official journal of the Movement Disorder Society
影响因子：
--
作者：
Gut NK;Winn P
通讯作者：
Winn P
影响因子：
3.3
作者：
Gross, N. B.;Duncker, P. C.;Marshall, J. F.
通讯作者：
Marshall, J. F.