Development and cadherin-mediated control of prefrontal corticostriatal projections in mice.
Development and cadherin-mediated control of prefrontal corticostriatal projections in mice.
复制标题
DOI：
10.1016/j.isci.2023.108002
复制
发表时间：
2023-10-20
期刊：
影响因子：
5.8
通讯作者：
Benson, Deanna L.
中科院分区：
文献类型：
--
作者：
Mesias, Roxana E.;Zaki, Yosif;Guevara, Christopher A.;Friedman, Lauren G.;Hussein, Ayan;Therrien, Karen;Magee, Alexandra R.;Tzavaras, Nikolaos;Del Valle, Pamela;Baxter, Mark G.;Huntley, George W.;Benson, Deanna L.
行动与结果的关联取决于前额皮质（PFC）对背侧纹状体的投射。为了评估这些投射是如何形成的，我们测量了出生后发育的小鼠纹状体中 PFC 轴突模式、突触形成和功能成熟。使用热点分析，我们发现 PFC 轴突在出生后第一周形成类似成人的簇状终止模式，此后基本保持稳定。 PFC-纹状体突触强度在 P21 时与成人相似，而兴奋性突触密度直到成年为止都会增加。然后，我们测试了从皮质纹状体神经元中靶向删除候选粘附/引导蛋白 Cadherin-8 (Cdh8) 如何调节通路发育。突变小鼠的 PFC 轴突靶向能力减弱，背侧纹状体自发谷氨酸能突触活性降低。他们在行动结果学习中也表现出行为表现受损。数据显示，PFC-纹状体轴突通过早期定向生长模型形成纹状体区域，并且强调了 Cdh8 对对于行动-结果关联的形成至关重要的解剖和功能特征的重要贡献。 PFC-纹状体神经支配模式遵循发育的定向生长模型 皮质纹状体突触发生在较长的时间过程中持续进行 突触前 Cdh8 限制了纹状体中 PFC 轴突生长的程度 Rpb4-Cre 介导的 Cdh8 缺失损害了纹状体依赖性行动结果学习行为神经科学；发育神经科学；细胞神经科学
Action-outcome associations depend on prefrontal cortex (PFC) projections to the dorsal striatum. To assess how these projections form, we measured PFC axon patterning, synapse formation, and functional maturation in the postnatally developing mouse striatum. Using Hotspot analysis, we show that PFC axons form an adult-like pattern of clustered terminations in the first postnatal week that remains largely stable thereafter. PFC-striatal synaptic strength is adult-like by P21, while excitatory synapse density increases until adulthood. We then tested how the targeted deletion of a candidate adhesion/guidance protein, Cadherin-8 (Cdh8), from corticostriatal neurons regulates pathway development. Mutant mice showed diminished PFC axon targeting and reduced spontaneous glutamatergic synaptic activity in the dorsal striatum. They also exhibited impaired behavioral performance in action-outcome learning. The data show that PFC-striatal axons form striatal territories through an early, directed growth model and they highlight essential contributions of Cdh8 to the anatomical and functional features critical for the formation of action-outcome associations. Pattern of PFC-striatal innervation follows a directed growth model of development Corticostriatal synaptogenesis continues over an extended time course Presynaptic Cdh8 limits the extent of PFC axon growth in the striatum Rpb4-Cre mediated Cdh8 deletion impairs striatal-dependent action-outcome learning Neuroscience; Behavioral neuroscience; Developmental neuroscience; Cellular neuroscience
登录
查看更多内容
影响因子：
16.2
作者：
Basu, Raunak;Duan, Xin;Williams, Megan E.
通讯作者：
Williams, Megan E.
影响因子：
11
作者：
Chang H;Hoshina N;Zhang C;Ma Y;Cao H;Wang Y;Wu DD;Bergen SE;Landén M;Hultman CM;Preisig M;Kutalik Z;Castelao E;Grigoroiu-Serbanescu M;Forstner AJ;Strohmaier J;Hecker J;Schulze TG;Müller-Myhsok B;Reif A;Mitchell PB;Martin NG;Schofield PR;Cichon S;Nöthen MM;Swedish Bipolar Study Group;MooDS Bipolar Consortium;Walter H;Erk S;Heinz A;Amin N;van Duijn CM;Meyer-Lindenberg A;Tost H;Xiao X;Yamamoto T;Rietschel M;Li M
通讯作者：
Li M
小鼠皮质-基底节-丘脑网络。
影响因子：
64.8
作者：
Foster NN;Barry J;Korobkova L;Garcia L;Gao L;Becerra M;Sherafat Y;Peng B;Li X;Choi JH;Gou L;Zingg B;Azam S;Lo D;Khanjani N;Zhang B;Stanis J;Bowman I;Cotter K;Cao C;Yamashita S;Tugangui A;Li A;Jiang T;Jia X;Feng Z;Aquino S;Mun HS;Zhu M;Santarelli A;Benavidez NL;Song M;Dan G;Fayzullina M;Ustrell S;Boesen T;Johnson DL;Xu H;Bienkowski MS;Yang XW;Gong H;Levine MS;Wickersham I;Luo Q;Hahn JD;Lim BK;Zhang LI;Cepeda C;Hintiryan H;Dong HW
通讯作者：
Dong HW
影响因子：
2.5
作者：
Calhoun, ME;Mao, Y;Rapp, PR
通讯作者：
Rapp, PR
影响因子：
5.3
作者：
Arruda-Carvalho, Maithe;Wu, Wan-Chen;Clem, Roger L.
通讯作者：
Clem, Roger L.