Ocular hemodynamics and glaucoma: the role of mathematical modeling.
Ocular hemodynamics and glaucoma: the role of mathematical modeling.
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DOI:
10.5301/ejo.5000255
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发表时间:
2013-03
影响因子:
1.7
通讯作者:
Siesky BA
中科院分区:
文献类型:
--
作者:
Harris A;Guidoboni G;Arciero JC;Amireskandari A;Tobe LA;Siesky BA
Many studies suggest that alterations in ocular hemodynamics can significantly impact the development, progression, and incidence of glaucoma. This article discusses the role of mathematical modeling in studying the relationship between ocular hemodynamics and glaucoma pathophysiology. Recent literature on glaucoma, ocular blood flow, autoregulation, the optic nerve head, and the use of mathematical modeling in ocular circulation was reviewed to summarize the current approaches used to investigate the relationship between vascular impairment and glaucoma progression. Mathematical models describing the mechanical, hemodynamic, and regulatory aspects of the ocular circulation have been developed. Preliminary modeling work shows the potential of mathematical models to elucidate the mechanisms that contribute most significantly to glaucoma progression. Mathematical modeling is a useful tool when used synergistically with clinical and laboratory data in the study of ocular blood flow and glaucoma. The development of models to investigate the relationship between ocular hemodynamic alterations and glaucoma progression will provide a unique and useful method for studying the pathophysiology of glaucoma.
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影响因子:
5.1
作者:
Anderson, DR
通讯作者:
Anderson, DR
DOI:
10.3129/i08-051
发表时间:
2008-06-01
影响因子:
4.2
作者:
Harris, Alon;Kagemann, Larry;Siesky, Brent
通讯作者:
Siesky, Brent
影响因子:
4.2
作者:
HAYREH, SS;ZIMMERMAN, MB;ALWARD, WLM
通讯作者:
ALWARD, WLM
DOI:
10.1152/ajpheart.00491.2001
发表时间:
2002-06-01
影响因子:
4.8
作者:
Cornelissen, AJM;Dankelman, J;Spaan, JAE
通讯作者:
Spaan, JAE
DOI:
10.1152/ajpheart.00262.2008
发表时间:
2008-10-01
影响因子:
4.8
作者:
Carlson, Brian E.;Arciero, Julia C.;Secomb, Timothy W.
通讯作者:
Secomb, Timothy W.