Ocular hemodynamics and glaucoma: the role of mathematical modeling.

Ocular hemodynamics and glaucoma: the role of mathematical modeling.
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DOI:
10.5301/ejo.5000255
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发表时间:
2013-03
影响因子:
1.7
通讯作者:
Siesky BA
Siesky BA
中科院分区:
医学4区
文献类型:
--
作者:
Harris A;Guidoboni G;Arciero JC;Amireskandari A;Tobe LA;Siesky BA

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许多研究表明,眼血流动力学的改变可以显著影响青光眼的发生、进展和发病率。本文讨论了数学建模在研究眼血流动力学与青光眼病理生理关系中的作用。本文综述了青光眼、眼血流、自身调节、视神经头以及眼循环数学模型的应用等方面的最新文献,总结了目前用于研究血管损伤与青光眼进展之间关系的方法。描述眼循环的力学、血流动力学和调节方面的数学模型已经发展起来。初步的建模工作显示了数学模型在阐明青光眼进展机制方面的潜力。当与临床和实验室数据协同使用时,数学模型是一种有用的工具,用于眼血流和青光眼的研究。研究眼部血流动力学改变与青光眼进展关系的模型的建立将为青光眼的病理生理学研究提供一种独特而有用的方法。
Many studies suggest that alterations in ocular hemodynamics can significantly impact the development, progression, and incidence of glaucoma. This article discusses the role of mathematical modeling in studying the relationship between ocular hemodynamics and glaucoma pathophysiology. Recent literature on glaucoma, ocular blood flow, autoregulation, the optic nerve head, and the use of mathematical modeling in ocular circulation was reviewed to summarize the current approaches used to investigate the relationship between vascular impairment and glaucoma progression. Mathematical models describing the mechanical, hemodynamic, and regulatory aspects of the ocular circulation have been developed. Preliminary modeling work shows the potential of mathematical models to elucidate the mechanisms that contribute most significantly to glaucoma progression. Mathematical modeling is a useful tool when used synergistically with clinical and laboratory data in the study of ocular blood flow and glaucoma. The development of models to investigate the relationship between ocular hemodynamic alterations and glaucoma progression will provide a unique and useful method for studying the pathophysiology of glaucoma.
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