Assessment of myocardial metabolic disorder associated with mediastinal radiotherapy for esophageal cancer -a pilot study.
Assessment of myocardial metabolic disorder associated with mediastinal radiotherapy for esophageal cancer -a pilot study.
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DOI：
10.1186/s13014-015-0410-z
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发表时间：
2015-04-21
期刊：
影响因子：
--
通讯作者：
Jingu K
中科院分区：
文献类型：
--
作者：
Umezawa R;Takanami K;Kadoya N;Nakajima Y;Saito M;Ota H;Matsushita H;Sugawara T;Kubozono M;Yamamoto T;Ishikawa Y;Takeda K;Taki Y;Takase K;Jingu K
目的：应用123-β-甲基碘苯基十五烷酸（I-123 BMIPP）心肌显像评价纵隔放射治疗（RT）后心肌代谢紊乱的量效关系。在2011年和2012年之间，我们对食管癌患者进行了I-123 BMIPP放射性成像，在治疗性纵隔RT之前和之后6个月。RT前和RT后的单光子发射计算机断层扫描（SPECT）图像被记录到RT剂量分布中。绘制心肌轮廓，计算局部RT剂量。需要进行归一化以比较RT前后SPECT图像，因为摄取模式会因呼吸水平而改变。对接受小于5戈伊的心肌区域的SPECT计数的平均值进行归一化。根据每个患者的标准化计算每个剂量区域（间隔5戈伊）的相对值。计算相对值百分比的降低。本研究入组了5例患者。所有患者均无心脏病既往史。所有患者的RT野均部分累及左心室。患者接受了放疗，原发肿瘤和转移淋巴结的中位总剂量为60-66戈伊。4例患者同时接受顺铂或奈达铂和5-氟尿嘧啶联合RT化疗。所有患者的放射性摄取均减少。在放疗后6个月时观察到摄取减少的剂量-效应关系，10-15戈伊区域平均减少8.96%，20-25戈伊区域平均减少12.6%，30-35戈伊区域平均减少15.6%，40-45戈伊区域平均减少19.0%，50-55戈伊区域平均减少16.0%。倾向于观察到心肌代谢紊乱的剂量-效应关系。我们可能需要在RT计划中努力减少对心肌的高剂量纵隔RT。
To evaluate the dose-effect relations for myocardial metabolic disorders after mediastinal radiotherapy (RT) by performing iodine-123 β-methyl-iodophenyl pentadecanoic acid (I-123 BMIPP) scintigraphy. Between 2011 and 2012, we performed I-123 BMIPP scintigraphy for patients with esophageal cancer before and six months after curative mediastinal RT. Single photon emission computed tomography (SPECT) images of pre-RT and post-RT were registered into RT dose distributions. The myocardium was contoured, and the regional RT dose was calculated. Normalization is required to compare pre- and post-RT SPECT images because the uptake pattern is changed due to the breathing level. Normalization was applied on the mean of SPECT counts in regions of the myocardium receiving less than 5 Gy. Relative values in each dose region (interval of 5 Gy) were calculated on the basis of this normalization for each patient. The reduction in the percent of relative values was calculated. Five patients were enrolled in this study. None of the patients had a past history of cardiac disease. The left ventricle was partially involved in RT fields in all patients. The patients received RT with median total doses of 60-66 Gy for the primary tumor and metastatic lymph nodes. Concomitant chemotherapy consisting of cisplatin or nedaplatin and 5-fluorouracil with RT was performed in 4 patients. All patients had reduced uptake corresponding to RT fields. Dose-effect relations for reduced uptake tended to be observed at 6 months after RT with mean decreases of 8.96% in regions at 10-15 Gy, 12.6% in regions at 20-25 Gy, 15.6% in regions at 30-35 Gy, 19.0% in regions at 40-45 Gy and 16.0% in regions at 50-55 Gy. Dose-effect relations for myocardial metabolic disorders tended to be observed. We may need to make an effort to reduce high-dose mediastinal RT to the myocardium in RT planning.
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影响因子：
3.7
作者：
Barjaktarovic Z;Schmaltz D;Shyla A;Azimzadeh O;Schulz S;Haagen J;Dörr W;Sarioglu H;Schäfer A;Atkinson MJ;Zischka H;Tapio S
通讯作者：
Tapio S
影响因子：
5.7
作者：
McGale, Paul;Darby, Sarah C.;Ewertz, Marianne
通讯作者：
Ewertz, Marianne
DOI：
10.1016/s0360-3016(00)00454-5
发表时间：
2000-06-01
影响因子：
7
作者：
Theuws, JCM;Baas, P;Lebesque, JV
通讯作者：
Lebesque, JV
影响因子：
2.8
作者：
NESTO, RW;KOWALCHUK, GJ
通讯作者：
KOWALCHUK, GJ
DOI：
10.1016/j.ijrobp.2005.01.029
发表时间：
2005-09-01
影响因子：
7
作者：
Marks, LB;Yu, XL;Borges-Neto, S
通讯作者：
Borges-Neto, S