Serological Evidence of Widespread Zika Transmission across the Philippines.
Serological Evidence of Widespread Zika Transmission across the Philippines.
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DOI：
10.3390/v13081441
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发表时间：
2021-07-23
期刊：
影响因子：
--
通讯作者：
Hafalla JCR
中科院分区：
文献类型：
--
作者：
Biggs JR;Sy AK;Brady OJ;Kucharski AJ;Funk S;Tu YH;Reyes MAJ;Quinones MA;Jones-Warner W;Ashall J;Avelino FL;Sucaldito NL;Tandoc AO;Cutiongco-de la Paz E;Capeding MRZ;Padilla CD;Hibberd ML;Hafalla JCR
在包括菲律宾在内的黄病毒流行国家，寨卡病毒（ZIKV）的暴露在很大程度上仍然未知，尽管有零星的病例报告和传播的环境适宜性。使用2016年的实验室监测数据，从菲律宾各地的疑似登革热（DENV）病例报告中随机选择了997份血清样本，并测定了短期（IgM）和长期（IgG）ZIKV暴露的血清学标志物。使用混合模型，我们重新评估了ZIKV IgM/G血清阳性率阈值，并使用催化模型来量化来自年龄累积ZIKV暴露的感染力（发作率，AR）。虽然我们观察到广泛的ZIKV/DENV IgG交叉反应性，但并非所有具有活动性DENV的个体都呈现升高的ZIKV IgG，并且一部分登革热阴性病例（DENV IgG-）是ZIKV IgG阳性的（14.3%，9/63）。我们确定了菲律宾各地区长期但非短期ZIKV暴露的证据（ZIKV IgG+：31.5%，314/997），这与DENV暴露在地理上不相关。与DENV AR（12.7%（95%CI：9.1-17.4%））相比，ZIKV AR在全国范围内较低（5.7%（95%CI：3-11%））。我们的研究结果提供了在菲律宾广泛暴露ZIKV的证据，并表明需要进行研究，以确定ZIKV感染的风险因素，以更好地为未来潜在的疫情做好准备。
Zika virus (ZIKV) exposure across flavivirus-endemic countries, including the Philippines, remains largely unknown despite sporadic case reporting and environmental suitability for transmission. Using laboratory surveillance data from 2016, 997 serum samples were randomly selected from suspected dengue (DENV) case reports across the Philippines and assayed for serological markers of short-term (IgM) and long-term (IgG) ZIKV exposure. Using mixture models, we re-evaluated ZIKV IgM/G seroprevalence thresholds and used catalytic models to quantify the force of infection (attack rate, AR) from age-accumulated ZIKV exposure. While we observed extensive ZIKV/DENV IgG cross-reactivity, not all individuals with active DENV presented with elevated ZIKV IgG, and a proportion of dengue-negative cases (DENV IgG-) were ZIKV IgG-positive (14.3%, 9/63). We identified evidence of long-term, yet not short-term, ZIKV exposure across Philippine regions (ZIKV IgG+: 31.5%, 314/997) which was geographically uncorrelated with DENV exposure. In contrast to the DENV AR (12.7% (95%CI: 9.1–17.4%)), the ZIKV AR was lower (5.7% (95%CI: 3–11%)) across the country. Our results provide evidence of widespread ZIKV exposure across the Philippines and suggest the need for studies to identify ZIKV infection risk factors over time to better prepare for potential future outbreaks.
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影响因子：
3.8
作者：
Morales I;Rosenberger KD;Magalhaes T;Morais CNL;Braga C;Marques ETA;Calvet GA;Damasceno L;Brasil P;Bispo de Filippis AM;Tami A;Bethencourt S;Alvarez M;Martínez PA;Guzman MG;Souza Benevides B;Caprara A;Quyen NTH;Simmons CP;Wills B;de Lamballerie X;Drexler JF;Jaenisch T;IDAMS Clinical Study Group
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IDAMS Clinical Study Group
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Leo, Yee Sin
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7.7
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Henderson, Alasdair D.;Aubry, Maite;Kucharski, Adam J.
通讯作者：
Kucharski, Adam J.
影响因子：
4.6
作者：
George J;Valiant WG;Mattapallil MJ;Walker M;Huang YS;Vanlandingham DL;Misamore J;Greenhouse J;Weiss DE;Verthelyi D;Higgs S;Andersen H;Lewis MG;Mattapallil JJ
通讯作者：
Mattapallil JJ
影响因子：
15.8
作者：
Brady, Oliver J.;Osgood-Zimmerman, Aaron;Marinho, Fatima
通讯作者：
Marinho, Fatima