Peptide design for antimicrobial and immunomodulatory applications.
Peptide design for antimicrobial and immunomodulatory applications.
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DOI：
10.1002/bip.22250
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发表时间：
2013-11
期刊：
影响因子：
2.9
通讯作者：
Hancock, Robert E. W.
中科院分区：
文献类型：
--
作者：
Haney, Evan F.;Hancock, Robert E. W.
病原菌对抗生素耐药性的威胁日益增加，可用于防治这些感染的抗生素供应日益减少，这对全世界的人类健康构成了重大威胁。抗菌肽长期以来一直被吹捧为能够填补抗感染空白的下一代抗生素。不幸的是，基于肽的抗生素尚未实现其作为新型药物的潜力，尽管有大量已知的抗微生物肽序列和我们对它们的抗菌作用机制的更好理解。最近，某些抗微生物肽的免疫调节特性已被认识到。小的合成肽在体内保护免受感染的能力已经证明，先天免疫应答的调节是进一步开发肽作为新型抗感染剂的有效策略。本文综述了用于评估新型肽序列抗菌和免疫调节特性的筛选方法。它还将研究我们如何在识别和优化具有所需生物学特性和增强治疗潜力的肽的能力方面取得进展。此外，目前的挑战，开发的肽作为抗感染药物进行检查和正在使用的策略，以克服这些问题进行了讨论。
The increasing threat of antibiotic resistance in pathogenic bacteria and the dwindling supply of antibiotics available to combat these infections poses a significant threat to human health throughout the world. Antimicrobial peptides have long been touted as the next generation of antibiotics capable of filling the anti-infective void. Unfortunately, peptide based antibiotics have yet to realize their potential as novel pharmaceuticals, in spite of the immense number of known antimicrobial peptide sequences and our improved understanding of their antibacterial mechanism of action. Recently, the immunomodulatory properties of certain antimicrobial peptides have become appreciated. The ability of small synthetic peptides to protect against infection in vivo has demonstrated that modulation of the innate immune response is an effective strategy to further develop peptides as novel anti-infectives. This review focuses on the screening methods that have been employed to assess novel peptide sequences for their antibacterial and immunomodulatory properties. It will also examine how we have progressed in our ability to identify and optimize peptides with desired biological characteristics and enhanced therapeutic potential. In addition, the current challenges to the development of peptides as anti-infectives are examined and the strategies being used to overcome these issues are discussed.
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