MAFLD enhances clinical practice for liver disease in the Asia-Pacific region.
MAFLD enhances clinical practice for liver disease in the Asia-Pacific region.
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DOI：
10.3350/cmh.2021.0310
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发表时间：
2022-04
影响因子：
8.9
通讯作者：
Torimura, Takuji
中科院分区：
文献类型：
--
作者：
Kawaguchi, Takumi;Tsutsumi, Tsubasa;Nakano, Dan;Eslam, Mohammed;George, Jacob;Torimura, Takuji
脂肪肝现在是亚太地区肝脏疾病的主要原因。这一地区的肝病具有鲜明的特点。首先，脂肪肝经常出现在瘦/正常体重的人身上。然而，这种独特的表型没有标准的定义。其次，脂肪肝常见于伴发病毒性肝炎的患者。将病毒性肝炎排除在非酒精性脂肪性肝病之外限制了其价值，并有损于病毒性肝炎患者并存脂肪肝的调查和整体管理。第三，脂肪肝相关性肝细胞癌通常被归类为非B非C型肝细胞癌。第四，人口迅速老龄化，为老年患者制定切实可行的低强度运动计划势在必行。第五，大多数患者和非专业医疗保健专业人员仍然缺乏对脂肪肝在肝内和肝外疾病以及癌症方面的重要性的认识。最近，一个国际专家小组提出了脂肪肝的新定义：代谢功能障碍相关性脂肪肝(MAFLD)。MAFLD的一个特征是代谢功能障碍是诊断的先决条件。与地区性问题相关，MAFLD还提供了对瘦/正常体重个人的诊断标准。此外，MAFLD独立于任何伴随的肝病，包括病毒性肝炎。因此，在亚太地区，MAFLD可能是一个更合适的脂肪肝定义。在这篇综述中，我们介绍了脂肪肝的地区性特征，并讨论了MAFLD在改善该地区肝病临床实践方面的优势。
Fatty liver is now a major cause of liver disease in the Asia-Pacific region. Liver diseases in this region have distinctive characteristics. First, fatty liver is frequently observed in lean/normal-weight individuals. However, there is no standard definition of this unique phenotype. Second, fatty liver is often observed in patients with concomitant viral hepatitis. The exclusion of viral hepatitis from non-alcoholic fatty liver disease limits its value and detracts from the investigation and holistic management of coexisting fatty liver in patients with viral hepatitis. Third, fatty liver-associated hepatocellular carcinoma (HCC) is generally categorized as non-B non-C HCC. Fourth, the population is aging rapidly, and it is imperative to develop a practicable, low-intensity exercise program for elderly patients. Fifth, most patients and non-specialized healthcare professionals still lack an awareness of the significance of fatty liver both in terms of intrahepatic and extrahepatic disease and cancer. Recently, an international expert panel proposed a new definition of fatty liver: metabolic dysfunction-associated fatty liver disease (MAFLD). One feature of MAFLD is that metabolic dysfunction is a prerequisite for diagnosis. Pertinent to regional issues, MAFLD also provides its diagnostic criteria in lean/normal-weight individuals. Furthermore, MAFLD is independent of any concomitant liver disease, including viral hepatitis. Therefore, MAFLD may be a more suitable definition for fatty liver in the Asia-Pacific region. In this review, we introduce the regional characteristics of fatty liver and discuss the advantages of MAFLD for improving clinical practice for liver disease in the region.
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全国对日本的调查中，肝细胞癌复杂肝硬化的病因过渡。
影响因子：
6.3
作者：
Enomoto H;Ueno Y;Hiasa Y;Nishikawa H;Hige S;Takikawa Y;Taniai M;Ishikawa T;Yasui K;Takaki A;Takaguchi K;Ido A;Kurosaki M;Kanto T;Nishiguchi S;Japan Etiology of Liver Cirrhosis Study Group in the 54th Annual Meeting of JSH
通讯作者：
Japan Etiology of Liver Cirrhosis Study Group in the 54th Annual Meeting of JSH
DOI：
10.1002/jcsm.12754
发表时间：
2021-10
期刊：
Journal of cachexia, sarcopenia and muscle
影响因子：
--
作者：
Chun HS;Kim MN;Lee JS;Lee HW;Kim BK;Park JY;Kim DY;Ahn SH;Kim SU
通讯作者：
Kim SU
影响因子：
7.6
作者：
Estes, Chris;Chan, Henry L. Y.;Razavi, Homie
通讯作者：
Razavi, Homie
影响因子：
35.7
作者：
Eslam, Mohammed;Alkhouri, Naim;George, Jacob
通讯作者：
George, Jacob
影响因子：
6.6
作者：
Cheng, Yu-Ming;Kao, Jia-Horng;Wang, Chia-Chi
通讯作者：
Wang, Chia-Chi