The generation and validation of white matter connectivity importance maps.
The generation and validation of white matter connectivity importance maps.
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DOI：
10.1016/j.neuroimage.2011.05.087
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发表时间：
2011-09-01
期刊：
影响因子：
5.7
通讯作者：
Raj, Ashish
中科院分区：
文献类型：
--
作者：
Kuceyeski, Amy;Maruta, Jun;Niogi, Sumit N.;Ghajar, Jamshid;Raj, Ashish
关键词：
大脑损伤的大小和位置都会影响认知或感觉运动功能障碍的类型和严重程度。然而，即使在磁共振成像和分析的进步，病变位置和临床缺陷之间的对应关系仍然知之甚少。在这里，来自14名健康受试者的结构和扩散图像被用于创建空间无偏的白色物质连接重要性图，该图量化了如果该区域受到损害，将对整个大脑网络造成的破坏量。白色物质中的一些区域被这种地图确定为非常重要的区域，这些区域与策略性梗死性痴呆有关，并与先前研究中的各种注意力任务有关。通过调查一组15名创伤性脑损伤患者的重要性图预测的认知缺陷与测量注意力和记忆力的认知测试分数的相关性来进行图的验证。虽然没有发现白色物质损伤的量和认知测试分数之间的相关性，但当包括重要性图中包含的位置信息时，发现了显著的相关性（r > 0.68，p < 0.006）。这些工具可以被医生用来改善手术计划，诊断和评估疾病严重程度的各种病理，如多发性硬化症，创伤和中风。
Both the size and location of injury in the brain influences the type and severity of cognitive or sensorimotor dysfunction. However, even with advances in MR imaging and analysis, the correspondence between lesion location and clinical deficit remains poorly understood. Here, structural and diffusion images from 14 healthy subjects are used to create spatially unbiased white matter connectivity importance maps that quantify the amount of disruption to the overall brain network that would be incurred if that region were compromised. Some regions in the white matter that were identified as highly important by such maps have been implicated in strategic infarct dementia and linked to various attention tasks in previous studies. Validation of the maps is performed by investigating the correlations of the importance maps’ predicted cognitive deficits in a group of 15 traumatic brain injury patients with their cognitive test scores measuring attention and memory. While no correlation was found between amount of white matter injury and cognitive test scores, significant correlations (r > 0.68, p < 0.006) were found when including location information contained in the importance maps. These tools could be used by physicians to improve surgical planning, diagnosis, and assessment of disease severity in a variety of pathologies like multiple sclerosis, trauma, and stroke.
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