Chemical Profiling of Xueshuan Xinmaining Tablet by HPLC and UPLC-ESI-Q-TOF/MS.
Chemical Profiling of Xueshuan Xinmaining Tablet by HPLC and UPLC-ESI-Q-TOF/MS.
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血栓心脉宁片的 HPLC 和 UPLC-ESI-Q-TOF/MS 化学分析
DOI：
10.1155/2018/2781597
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Liu CG
中科院分区：
文献类型：
--
作者：
Han YX;Wang PF;Zhao M;Chen LM;Wang ZM;Liu XQ;Gao HM;Gong MX;Li H;Zhu JZ;Liu CG
血栓心脉宁片（XXT）是一种广泛应用于治疗由血瘀引起的中风、胸痛、冠心病和心绞痛的中药。它是一种多成分制剂，但由于其详细的化学基础和作用机制尚未阐明，仍远不能满足现代化和标准化的要求。在这项工作中，采用高效液相色谱法（HPLC）对不同批次的XXT样品进行了分析，并采用超高效液相色谱 - 电喷雾电离 - 四极杆 - 飞行时间质谱（UPLC - ESI - Q - TOF/MS）对典型样品进行了分析，以了解其化学特征。结果检测到77个色谱峰，其中63种成分通过与标准化合物保留时间和紫外光谱的比较，以及总结的质谱裂解规律和经验分子式与已发表成分的匹配，得到了鉴定或初步表征。这是关于市售XXT产品化学特征的首份系统性报告，为XXT产品的整体质量评价提供了充分的化学依据。
Xueshuan Xinmaining Tablet (XXT) is a widely used traditional Chinese medicine for the treatment of stroke, chest pain, coronary heart disease, and angina pectoris caused by blood stasis. Having a multiple-component preparation, it is still far from meeting the requirements of modernization and standardization because its detailed chemical basis and action mechanism have not been clarified. In this work, the different batches of XXT samples were analyzed by HPLC and the typical sample was analyzed by UPLC-ESI-Q-TOF/MS to understand its chemical profiling. As a result, 77 chromatographic peaks were detected, among which 63 constituents were identified or tentatively characterized based on the comparison of retention time and UV spectra with authentic compounds as well as by summarized MS fragmentation rules and matching of empirical molecular formula with those of published components. This is the first systematic report on the chemical profiling of the commercial XXT products, which provides the sufficiently chemical evidence for the global quality evaluation of XXT products.
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DOI：
10.1155/2016/7895935
发表时间：
2016
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Dong H;Ren JX;Wang JJ;Ding LS;Zhao JJ;Liu SY;Gao HM
通讯作者：
Gao HM
DOI：
10.3390/molecules201018597
发表时间：
2015-10-14
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Chen D;Lin S;Xu W;Huang M;Chu J;Xiao F;Lin J;Peng J
通讯作者：
Peng J
影响因子：
2
作者：
Qi, Lian-Wen;Chen, Chun-Yun;Li, Ping
通讯作者：
Li, Ping
影响因子：
2
作者：
Ye, M;Guo, DA
通讯作者：
Guo, DA
通过 HPLC 和 LC-DAD-MS/MS 比较不同蟾蜍种类的蟾蜍毒液
影响因子：
5.4
作者：
Gao, Huimin;Zehl, Martin;Kopp, Brigitte
通讯作者：
Kopp, Brigitte