Bone-forming perivascular cells: Cellular heterogeneity and use for tissue repair.
Bone-forming perivascular cells: Cellular heterogeneity and use for tissue repair.
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血管周围细胞：细胞异质性和用于组织修复的用途。
DOI：
10.1002/stem.3436
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发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
James AW
中科院分区：
文献类型：
--
作者：
Xu J;Wang Y;Gomez-Salazar MA;Hsu GC;Negri S;Li Z;Hardy W;Ding L;Peault B;James AW
间充质祖细胞广泛分布在血管周围的壁龛-物种之间保守的观察。在哺乳动物组织中具有高频率间充质祖细胞的一个常见组织学区域是外膜（图尼卡），即由具有成纤维细胞形态的细胞聚集的血管壁的外层。目前在这个最外层的血管周围生态位的（再生）再生细胞的多样性和功能正在紧张的调查中，我们在这里回顾了我们目前的知识外膜细胞的潜力，有点狭窄的重点骨形成。讨论了功能性分离前叶细胞的感兴趣的抗原，包括CD 10、CD 107 a、ALDH同种型和CD 140 a等。纯化的外膜细胞（如CD 10+、CD 107 alow和CD 140 a+细胞）具有更强的成骨潜能，并促进体内骨形成。最后介绍了外膜细胞在骨组织工程中的应用。对血管周围祖细胞亚群的更好理解可能代表了组织修复和生物工程未来努力的有益进展。图尼卡外膜中的间充质祖细胞具有分化和增殖潜力的层次。最重要的是，PDGFRα+和ALDHHigh细胞显示出向成骨和成脂细胞谱系分化的双能分化潜力，具有高增殖率。相反，CD 10和CD 107 a表达分别将成骨祖细胞与成脂祖细胞分开。此外，骨祖细胞可以转变为成脂表型。
Mesenchymal progenitor cells are broadly distributed across perivascular niches – an observation conserved between species. One common histologic zone with a high frequency of mesenchymal progenitor cells within mammalian tissues is the tunica adventitia, the outer layer of blood vessel walls populated by cells with a fibroblastic morphology. The diversity and functions of (re)generative cells present in this outermost perivascular niche are under intense investigation; we have reviewed herein our current knowledge of adventitial cell potential with a somewhat narrow focus on bone formation. Antigens of interest to functionally segregate adventicytes are discussed, including CD10, CD107a, ALDH isoforms, and CD140a among others. Purified adventicytes (such as CD10+, CD107alow, and CD140a+ cells) have stronger osteogenic potential and promote bone formation in vivo. Recent bone tissue engineering applications of adventitial cells are also presented. A better understanding of perivascular progenitor cell subsets may represent a beneficial advance for future efforts in tissue repair and bioengineering. Mesenchymal progenitor cells in the tunica adventitia have a hierarchy of differentiation and proliferation potential. On top of the hierarchy, PDGFRα+ and ALDHHigh cells show a bi-potent differentiation potential into osteogenic and adipogenic cell lineages with high proliferative rate. Conversely, CD10 and CD107a expression separate osteogenic progenitors from adipogenic progenitors, respectively. Moreover, osteoprogenitors can transition into adipogenic phenotype.
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影响因子：
5.3
作者：
Crisan M;Corselli M;Chen WC;Péault B
通讯作者：
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影响因子：
4.6
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通讯作者：
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作者：
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通讯作者：
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