Chronic inflammatory diseases are stimulated by current lifestyle: how diet, stress levels and medication prevent our body from recovering.
Chronic inflammatory diseases are stimulated by current lifestyle: how diet, stress levels and medication prevent our body from recovering.
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DOI：
10.1186/1743-7075-9-32
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发表时间：
2012-04-17
影响因子：
4.5
通讯作者：
Pruimboom L
中科院分区：
文献类型：
--
作者：
Bosma-den Boer MM;van Wetten ML;Pruimboom L
Serhan和他的同事在1996年引入了“消炎组学”这个术语，作为消炎的过程。Serhan的工作的主要发现是炎症的开始到结束是免疫系统（is）的一个受控过程，而不仅仅是免疫反应消失或“耗尽”的结果。分辨率组学可以被认为是损伤、炎症和感染后恢复体内平衡的进化机制。在正常情况下，Resoleomics应该能够推断出炎症反应。考虑到涉及慢性炎症的慢性医学和精神疾病的现代流行病的增加，很明显，Resoleomics并没有发挥其潜在的解决能力。我们认为，最近生活方式的剧烈变化，包括饮食和心理情绪压力，是导致炎症和Resoleomics紊乱的原因。此外，目前的干预措施，如长期使用抗炎药物，会抑制抗衰老组学。这些新的生活方式因素，包括药物的使用，应被视为健康危害，因为它们能够长期或慢性地激活中央压力轴。IS的设计目的是为快速、密集的危险提供解决方案，而不是应对长期、慢性的刺激。近期生活方式变化带来的永无止境的压力因素，已经将IS和中枢压力系统推向了一种持续的活动状态，导致长期未解决的炎症和对慢性疾病的易感性增加。我们的假设是，现代饮食、增加的心理情绪压力和长期使用抗炎药物破坏了炎症消退的自然过程。
Serhan and colleagues introduced the term "Resoleomics" in 1996 as the process of inflammation resolution. The major discovery of Serhan's work is that onset to conclusion of an inflammation is a controlled process of the immune system (IS) and not simply the consequence of an extinguished or "exhausted" immune reaction. Resoleomics can be considered as the evolutionary mechanism of restoring homeostatic balances after injury, inflammation and infection. Under normal circumstances, Resoleomics should be able to conclude inflammatory responses. Considering the modern pandemic increase of chronic medical and psychiatric illnesses involving chronic inflammation, it has become apparent that Resoleomics is not fulfilling its potential resolving capacity. We suggest that recent drastic changes in lifestyle, including diet and psycho-emotional stress, are responsible for inflammation and for disturbances in Resoleomics. In addition, current interventions, like chronic use of anti-inflammatory medication, suppress Resoleomics. These new lifestyle factors, including the use of medication, should be considered health hazards, as they are capable of long-term or chronic activation of the central stress axes. The IS is designed to produce solutions for fast, intensive hazards, not to cope with long-term, chronic stimulation. The never-ending stress factors of recent lifestyle changes have pushed the IS and the central stress system into a constant state of activity, leading to chronically unresolved inflammation and increased vulnerability for chronic disease. Our hypothesis is that modern diet, increased psycho-emotional stress and chronic use of anti-inflammatory medication disrupt the natural process of inflammation resolution ie Resoleomics.
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影响因子：
33.7
作者：
Chan, Edwin S. L.;Cronstein, Bruce N.
通讯作者：
Cronstein, Bruce N.
影响因子：
7
作者：
Calder, Philip C.
通讯作者：
Calder, Philip C.
影响因子：
6.3
作者：
Desneves, KJ;Todorovic, BE;Crowe, TC
通讯作者：
Crowe, TC
影响因子：
4.4
作者：
Bannenberg, GL;Chiang, N;Serhan, CN
通讯作者：
Serhan, CN
DOI：
10.1016/j.plefa.2008.09.007
发表时间：
2008-09-01
影响因子：
3
作者：
Adam, O.;Tesche, A.;Wolfram, G.
通讯作者：
Wolfram, G.