Immunological Hyperresponsiveness in HTLV-I LTR-env-pX Transgenic Rats: A Prototype Animal Model for Collagen Vascular and HTLV-I-Related Inflammatory Diseases
Immunological Hyperresponsiveness in HTLV-I LTR-env-pX Transgenic Rats: A Prototype Animal Model for Collagen Vascular and HTLV-I-Related Inflammatory Diseases
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HTLV-I LTR-env-pX 转基因大鼠的免疫高反应性：胶原血管和 HTLV-I 相关炎症性疾病的原型动物模型
DOI：
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
T. Yoshiki
中科院分区：
文献类型：
--
作者：
Y. Nakamaru;A. Ishizu;H. Ikeda;T. Sugaya;K. Fugo;M. Higuchi;H. Yamazaki;T. Yoshiki
我们先前报道了携带人T淋巴细胞病毒I型LTR-env-pX基因的转基因大鼠（LTR-env-pX大鼠）中随着自身抗体的出现而发生的各种胶原血管疾病，包括关节炎、动脉炎、血栓形成、心肌炎、肌炎、唾液腺/泪腺炎和皮炎。为了阐明这些胶原血管疾病的发病机制，LTR-env-pX大鼠的免疫学特征进行了检查。在LTR-env-pX大鼠感染这些疾病，CD 80/86的表达在组织浸润和外周T细胞增加，与非转基因大鼠实验性炎症性疾病的研究结果相比。在疾病发展之前，LTR-env-pX大鼠外周T细胞上的CD 80/86也上调。LTR-env-pX大鼠的淋巴细胞显示出自体增殖的增加，并且对几种有丝分裂原具有高反应性，包括伴刀豆球蛋白A、固定化抗CD 3抗体和体外超抗原。LTR-env-pX大鼠的抗原特异性免疫应答也增强。集体证据表明，LTR-env-pX大鼠的淋巴细胞组成性表达与T细胞活化相关的表面分子，并且具有免疫高反应性。从LTR-env-pX大鼠骨髓细胞转移到致死剂量照射的非转基因大鼠显示，这些免疫预活化和高反应性淋巴细胞在几种胶原血管疾病的发病机制中起着关键作用，特别是在LTR-env-pX大鼠的皮炎。
We have earlier reported that diverse collagen vascular diseases, including arthritis, arteritis, thrombosis, myocarditis, myositis, sialo-/dacryoadenitis and dermatitis develop with the advent of autoantibodies in transgenic rats carrying the LTR-env-pX gene of human T lymphocyte virus type I (LTR-env-pX rats). To clarify the pathogenesis of these collagen vascular diseases, immunological features of LTR-env-pX rats were examined. In LTR-env-pX rats affected with these diseases, expression of CD80/86 on both tissue-infiltrating and peripheral T cells increased, compared with findings in non-transgenic rats with experimental inflammatory diseases. CD80/86 was also upregulated on peripheral T cells in LTR-env-pX rats prior to the development of diseases. Lymphocytes from LTR-env-pX rats showed an increase in autologous proliferation and were hyperreactive against several mitogens, including concanavalin A, immobilized anti-CD3 antibodies, and superantigens in vitro. Antigen-specific immune response was also enhanced in LTR-env-pX rats. The collective evidence indicates that lymphocytes of LTR-env-pX rats constitutively express surface molecules related to T cell activation and are immunologically hyperresponsive. Bone marrow cell transfer from LTR-env-pX rats to lethally irradiated non-transgenic rats revealed that these immunologically pre-activated and hyperresponsive lymphocytes play a critical role in the pathogenesis of several collagen vascular diseases, especially of dermatitis in LTR-env-pX rats.
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影响因子：
56.9
作者：
FREEMAN, GJ;GRIBBEN, JG;NADLER, LM
通讯作者：
NADLER, LM
mAb 104 是一种新型单克隆抗体，可识别活化 B 细胞和 HTLV-1 转化 T 细胞上表达的 B7 抗原。
影响因子：
6.4
作者：
Valle,A;Garrone,P;Yssel,H;Bonnefoy,JY;Freedman,AS;Freeman,G;Nadler,LM;Banchereau,J
通讯作者：
Banchereau,J
影响因子：
8
作者：
K. Sakamoto;S. Nimer;J. Rosenblatt;J. Gasson
通讯作者：
K. Sakamoto;S. Nimer;J. Rosenblatt;J. Gasson
IL-2 激活的外周血淋巴细胞裂解角质形成细胞。
DOI：
10.1111/1523-1747.ep12515933
发表时间：
1991
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Symington,FW;Santos,EB
通讯作者：
Santos,EB