Absence of regional hemispheric volume asymmetries in first-episode schizophrenia.
Absence of regional hemispheric volume asymmetries in first-episode schizophrenia.
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首发精神分裂症不存在局部半球体积不对称。
DOI：
10.1176/ajp.151.10.1437
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Lieberman,JA
中科院分区：
文献类型：
--
作者：
Bilder,RM;Wu,H;Bogerts,B;Degreef,G;Ashtari,M;Alvir,JM;Snyder,PJ;Lieberman,JA
本研究的目的是确定首次发作的精神分裂症患者是否与健康受试者在大脑半球区域体积或不对称性方面存在差异。对70例首次发病的精神分裂症患者和51例健康对照者在连续冠状面磁共振图像上测量了每个半球的颞叶和颞叶结果患者在区域或总半球体积方面与cornostransomers受试者没有差异，但他们有异常的半球不对称性。对照组的受试者在每个区域都有明显的横向不对称：他们的枕顶和感觉运动区域在左侧较大，而他们的运动前区、前额区和颞区在右侧较大。患者缺乏横向不对称性，枕顶、运动前区和前额区的不对称性明显低于健康受试者。在最初诊断为未分化型精神分裂症的患者中，正常不对称性的缺失比偏执型精神分裂症患者更常见，并且与男性中更严重的阴性症状相关。无论诊断如何，不对称性都与性别和惯用手有关;具体来说，右手男性比非右手男性或右手女性表现出更多的不对称性。结论正常半球不对称的缺乏表明精神分裂症侧向专门大脑系统发育异常，这可能与非偏执型精神病的最初表现有关。
ObjectiveThe goal ofthis study was to determine whether patients experiencing their first episode ofschizophrenia differ from healthy subjects in regional cerebral hemispheric volumes or asymmetries.MethodRegional volumes corresponding to prefrontal, premotor, sensorimotor, occipitoparietal, and temporal lobes in each hemisphere were measured on contiguous coronal magnetic resonance images in 70 patients experiencing their first episode of schizophrenia and in 51 healthy comparison subjects.ResultsPatients did not differ from the cornparison subjects in regional or total hemispheric volumes, but they had abnormal hemispheric asymmetries. Subjects in the comparison group had significant lateral asymmetries in each region: their occipitoparietal and sensorimotor regions were larger on the left, and their premotor, prefrontal, and temporal regions were larger on the right. Patients lacked lateral asymmetries and showed significantly less asymmetry than healthy subjects in occipitoparietal, premotor, and prefrontal regions. Absence of the normal asymmetry was more common among patients initially diagnosed with the undifferentiated than with the paranoid subtype ofschizophrenia and was associated with more severe negative symptoms among men. Asymmetries were related to sex and handedness regardless of diagnosis; specifically, dextral men showed more asymmetry than nondextral men or dextral women.ConclusionsThe absence of normal hemispheric asymmetries suggests an anomaly in the development oflaterally specialized cerebral systems in schizophrenia, and this may be associated with an initial presentation of nonparanoid psychosis.
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